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Metallo β-lactamase ligand 1

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Catalog No. T38476Cas No. 1087784-71-1

Metallo β-lactamase ligand 1 is an inhibitor of class B β-lactamase exhibiting antibacterial activities.

Metallo β-lactamase ligand 1

Metallo β-lactamase ligand 1

🥰Excellent
Purity: 97.72%
Catalog No. T38476Cas No. 1087784-71-1
Metallo β-lactamase ligand 1 is an inhibitor of class B β-lactamase exhibiting antibacterial activities.
Pack SizePriceAvailabilityQuantity
10 mg$35In Stock
25 mg$69In Stock
50 mg$98In Stock
100 mg$157In Stock
200 mg$236In Stock
1 mL x 10 mM (in DMSO)$29In Stock
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Purity:97.72%
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Product Introduction

Bioactivity
Description
Metallo β-lactamase ligand 1 is an inhibitor of class B β-lactamase exhibiting antibacterial activities.
In vitro
The toxicity of Metallo β-lactamase ligand 1 is extremely low in HeLa cells[1].
In vivo
Administration of Metallo β-lactamase ligand 1 significantly improves the survival rate in mice infected with an experimental strain (E. coli strain into which a plasmid encoding class B β-lactamase (IMP-1) is introduced)[1].
Chemical Properties
Molecular Weight219.22
FormulaC7H9NO5S
Cas No.1087784-71-1
SmilesS(N)(=O)(=O)C=1C(C(O)=O)=C(C)OC1C
Relative Density.1.498 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/mL (250.9 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.5616 mL22.8081 mL45.6163 mL228.0814 mL
5 mM0.9123 mL4.5616 mL9.1233 mL45.6163 mL
10 mM0.4562 mL2.2808 mL4.5616 mL22.8081 mL
20 mM0.2281 mL1.1404 mL2.2808 mL11.4041 mL
50 mM0.0912 mL0.4562 mL0.9123 mL4.5616 mL
100 mM0.0456 mL0.2281 mL0.4562 mL2.2808 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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