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Methyl pyropheophorbide-a
🥰Excellent
Catalog No. T33492Cas No. 6453-67-4
Alias Pyropheophorbide-a methyl ester, Pyropheophorbidea, NSC-267052, NSC267052, NSC 267052, MPPa
Methyl pyropheophorbide-a (MPPa) is a chlorine photosensitizer and a derivative of chlorophyll a. It is photodynamically active, induces apoptosis and inhibits tumor growth, and can be used in photodynamic therapy (PDT) of cancer.
Methyl pyropheophorbide-a
🥰Excellent
Purity: 98.17%
Catalog No. T33492Alias Pyropheophorbide-a methyl ester, Pyropheophorbidea, NSC-267052, NSC267052, NSC 267052, MPPaCas No. 6453-67-4
Methyl pyropheophorbide-a (MPPa) is a chlorine photosensitizer and a derivative of chlorophyll a. It is photodynamically active, induces apoptosis and inhibits tumor growth, and can be used in photodynamic therapy (PDT) of cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $32 | In Stock |
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Purity:98.17%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Methyl pyropheophorbide-a (MPPa) is a chlorine photosensitizer and a derivative of chlorophyll a. It is photodynamically active, induces apoptosis and inhibits tumor growth, and can be used in photodynamic therapy (PDT) of cancer. |
| In vitro | In PC-3M cells, after treatment with Methyl pyropheophorbide-a (2 μM; 12 h) under LC75 conditions (2 μM + 55.6 kJ/m²), the apoptosis rates were approximately 0.27%, 6.15%, 20.49%, 50.76%, 65.39%, 64.92%, and 64.37% at 1, 3, 6, 12, 18, and 24 hours post-treatment, respectively[1]. |
| In vivo | In male BALB/c nude mice (6-8 weeks old, 16-20 g) bearing PC-3M tumors, Methyl pyropheophorbide-a (15 mg/kg; tail vein injection and topical injection) resulted in tumor volume and weight inhibition rates of 46.78% and 41.84% in the tail vein injection group, respectively, and 78.66% and 72.07% in the topical injection group, respectively[2]. |
| Alias | Pyropheophorbide-a methyl ester, Pyropheophorbidea, NSC-267052, NSC267052, NSC 267052, MPPa |
| Molecular Weight | 548.67 |
| Formula | C34H36N4O3 |
| Cas No. | 6453-67-4 |
| Smiles | CCc1c(C)c2cc3[nH]c(cc4nc([C@@H](CCC(=O)OC)[C@@H]4C)c4CC(=O)c5c(C)c(cc1n2)[nH]c45)c(C)c3C=C |
| Relative Density. | 1.28 g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||
| Solubility Information | DMSO: 1 mg/mL (1.82 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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