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Methyl pyropheophorbide-a
Catalog No. T33492Cas No. 6453-67-4
Methyl pyropheophorbide-a (MPPa) is a chlorine photosensitizer and a derivative of chlorophyll a. It is photodynamically active, induces apoptosis and inhibits tumor growth, and can be used in photodynamic therapy (PDT) of cancer.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $32 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Methyl pyropheophorbide-a (MPPa) is a chlorine photosensitizer and a derivative of chlorophyll a. It is photodynamically active, induces apoptosis and inhibits tumor growth, and can be used in photodynamic therapy (PDT) of cancer. |
| In vitro | In PC-3M cells, after treatment with Methyl pyropheophorbide-a (2 μM; 12 h) under LC75 conditions (2 μM + 55.6 kJ/m²), the apoptosis rates were approximately 0.27%, 6.15%, 20.49%, 50.76%, 65.39%, 64.92%, and 64.37% at 1, 3, 6, 12, 18, and 24 hours post-treatment, respectively[1]. |
| In vivo | In male BALB/c nude mice (6-8 weeks old, 16-20 g) bearing PC-3M tumors, Methyl pyropheophorbide-a (15 mg/kg; tail vein injection and topical injection) resulted in tumor volume and weight inhibition rates of 46.78% and 41.84% in the tail vein injection group, respectively, and 78.66% and 72.07% in the topical injection group, respectively[2]. |
| Alias | MPPa, NSC267052, Pyropheophorbidea, NSC-267052, Pyropheophorbide-a methyl ester, NSC 267052 |
| Molecular Weight | 548.67 |
| Formula | C34H36N4O3 |
| Cas No. | 6453-67-4 |
| Storage | store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||
| Solubility Information | DMSO: 1 mg/mL (1.82 mM) | ||||||||||
Solution Preparation Table | |||||||||||
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