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MK-6892
Catalog No. TQ0108Cas No. 917910-45-3
MK-6892 is a selective and full agonist for the high-affinity nicotinic acid receptor GPR109A (Ki: 4 nM; GTPγS EC50: 16 nM).
MK-6892
Catalog No. TQ0108Cas No. 917910-45-3
MK-6892 is a selective and full agonist for the high-affinity nicotinic acid receptor GPR109A (Ki: 4 nM; GTPγS EC50: 16 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $98 | In Stock | |
| 5 mg | $198 | In Stock | |
| 10 mg | $297 | In Stock | |
| 25 mg | $497 | In Stock | |
| 50 mg | $689 | In Stock | |
| 100 mg | $993 | In Stock | |
| 500 mg | $1,980 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $243 | In Stock |
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Purity:99.03%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | MK-6892 is a selective and full agonist for the high-affinity nicotinic acid receptor GPR109A (Ki: 4 nM; GTPγS EC50: 16 nM). |
| Targets&IC50 | GPR109A:16 nM (EC50), GPR109A:4 nM (Ki) |
| In vitro | MK-6892 effectively induces the internalization of GPR109A in U2OS β-arrestin2-RrGFP cells and demonstrates a potent EC50 of 74 nM in calcium mobilization assays [2]. |
| In vivo | MK-6892 is administered orally to WT and nicotinic acid (NA) receptor null mice on a C57Bl/6 genetic background. Following a 100 mg/kg dose, blood levels of MK-6892 reach 229 μM in WT mice and 148 μM in NA receptor null mice after 15 minutes, significantly exceeding the in vitro EC50 (240 nM). MK-6892 effectively suppresses plasma FFA in WT mice, but not in NA receptor null mice, indicating NA receptor-dependent FFA reduction [1]. |
| Molecular Weight | 386.4 |
| Formula | C19H22N4O5 |
| Cas No. | 917910-45-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (116.46 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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