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ML359

🥰Excellent
Catalog No. T25821Cas No. 1069858-99-6
Alias ML-359, ML 359

ML359 is a protein disulfide isomerase inhibitor.

ML359

ML359

🥰Excellent
Purity: 99.16%
Catalog No. T25821Alias ML-359, ML 359Cas No. 1069858-99-6
ML359 is a protein disulfide isomerase inhibitor.
Pack SizePriceAvailabilityQuantity
1 mg$83In Stock
5 mg$197In Stock
10 mg$332In Stock
25 mg$558In Stock
50 mg$788In Stock
100 mg$1,120In Stock
1 mL x 10 mM (in DMSO)$232In Stock
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Purity:99.16%
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Product Introduction

Bioactivity
Description
ML359 is a protein disulfide isomerase inhibitor.
Targets&IC50
Protein disulfide isomerase:250 nM (IC50)
In vitro
ML359 shown to be a specific inhibitor of PDI.?ML359 shows no cytotoxicity in three human cell lines, and some activity in inhibiting platelet aggregation in vitro.?ML359 will provide more understanding of the mechanisms of PDI in platelet functions.?It also could lead to the development of a new class of antithrombotics that could establish PDI as suitable drug target.
AliasML-359, ML 359
Chemical Properties
Molecular Weight417.93
FormulaC23H28ClNO4
Cas No.1069858-99-6
SmilesCCOC(=O)C1(CCOc2ccccc2)CCN(Cc2ccc(O)c(Cl)c2)CC1
Relative Density.1.212 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 84 mg/mL (200.99 mM)
Ethanol: 84 mg/mL (200.99 mM)
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM2.3927 mL11.9637 mL23.9275 mL119.6373 mL
5 mM0.4785 mL2.3927 mL4.7855 mL23.9275 mL
10 mM0.2393 mL1.1964 mL2.3927 mL11.9637 mL
20 mM0.1196 mL0.5982 mL1.1964 mL5.9819 mL
50 mM0.0479 mL0.2393 mL0.4785 mL2.3927 mL
100 mM0.0239 mL0.1196 mL0.2393 mL1.1964 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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