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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | Inquiry | 1-2 weeks | |
50 mg | Inquiry | 1-2 weeks | |
100 mg | Inquiry | 1-2 weeks |
Description | MMAF Hydrochloride is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF Hydrochloride is an effective tubulin polymerization inhibitor and is used as an antitumor compound. |
In vitro | MMAF suppresses anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O, and Caki-1 cells. It has IC50s of 119, 105, 257, and 200 nM in vitro cytotoxicity assay[4]. |
In vivo | cAC10-L1-MMAF4 has an MTD of 50 mg/kg in mice and 15 mg/kg in rats, whereas the cAC10-L4-MMAF4 ADC is much less toxic, with MTDs of >150 mg/kg in mice and 90 mg/kg in rats. The maximum tolerated dose of MMAF (>16 mg/kg) in mice is much higher than that of MMAE (1 mg/kg) [4]. |
Alias | Monomethylauristatin F Hydrochloride |
Molecular Weight | 768.42 |
Formula | C39H66ClN5O8 |
Cas No. | 1415246-68-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 27 mg/mL (35.14 mM), Sonication and heating are recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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