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MPO-IN-1 is an orally active myeloperoxidase (MPO) inhibitor, inhibiting MPO and thyroid peroxidase (TPO). It is useful in inflammation research.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $293 | In Stock | |
5 mg | $722 | In Stock | |
10 mg | $987 | In Stock | |
25 mg | $1,520 | In Stock | |
50 mg | $1,980 | In Stock | |
1 mL x 10 mM (in DMSO) | $333 | In Stock |
Description | MPO-IN-1 is an orally active myeloperoxidase (MPO) inhibitor, inhibiting MPO and thyroid peroxidase (TPO). It is useful in inflammation research. |
Targets&IC50 | MPO:2.6 μM |
In vitro | MPO-IN-1 is an irreversible indole-containing myeloperoxidase (MPO) inhibitor with an IC50 of 2.6 μM. [1] |
In vivo | The plasma concentration of mice was reduced in a biphasic manner after intravenous administration of MPO-IN-1 (1 mg/kg). The mean plasma elimination half-life (T1/2) was 2.6 h. Mpo-in-1 (5 mg/kg or 90 mg/kg orally) causes up-regulation of MPO activity IN the coated exudate in mice. [1] |
Molecular Weight | 400.9 |
Formula | C24H21ClN4 |
Cas No. | 2471981-21-0 |
Smiles | ClC=1C=CN=C2C1C(=CN2C3=CC=C(C=C3)CN(C)C)C=4C=CC=5C=CNC5C4 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 160 mg/mL (399.1 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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