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MS023 dihydrochloride

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Purity:99.52%

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COA HNMR HPLC

MS023 dihydrochloride

Catalog No. T61338Cas No. 1992047-64-9

MS023 dihydrochloride (MS023 2HCl) is a selective, cytosolic and highly potent inhibitor of human type I protein arginine methyltransferases (PRMTs) with antitumour activity, inhibits PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, and increases the proliferative capacity of isolated cultured MuSC. It can be used to study breast cancer.

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Pack Size	Price	Availability
5 mg	$77	In Stock
10 mg	$108	In Stock
25 mg	$179	In Stock
50 mg	$266	In Stock
100 mg	$395	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock

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Product Introduction

Bioactivity

Description	MS023 dihydrochloride (MS023 2HCl) is a selective, cytosolic and highly potent inhibitor of human type I protein arginine methyltransferases (PRMTs) with antitumour activity, inhibits PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, and increases the proliferative capacity of isolated cultured MuSC. It can be used to study breast cancer.
In vitro	MS023 dihydrochloride (1-1000 nM) effectively and concentration-dependently reduces PRMT1 methyltransferase activity in MCF7 cells[1].
In vivo	In NOD-scid IL2Rgnull (NSG) mice bearing primary MLL-r ALL cells, combinatorial treatment with MS023 dihydrochloride (160 mg/kg, ip) and PKC412 (100 mg/kg, i.g.) for 4 weeks extended the survival of leukemic mice compared to single treatments[2].
Alias	MS023 2HCl

Chemical Properties

Molecular Weight	360.32
Formula	C17H27Cl2N3O
Cas No.	1992047-64-9

Storage & Solubility Information

Storage

store under nitrogen Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 20 mg/mL (55.56 mM)

DMSO: 100 mg/mL (277.78 mM)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.7753 mL	13.8766 mL	27.7531 mL	138.7655 mL
5 mM	0.5551 mL	2.7753 mL	5.5506 mL	27.7531 mL
10 mM	0.2775 mL	1.3877 mL	2.7753 mL	13.8766 mL
20 mM	0.1388 mL	0.6938 mL	1.3877 mL	6.9383 mL
50 mM	0.0555 mL	0.2775 mL	0.5551 mL	2.7753 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0278 mL	0.1388 mL	0.2775 mL	1.3877 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc