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MS023 dihydrochloride (MS023 2HCl) is a selective, cytosolic and highly potent inhibitor of human type I protein arginine methyltransferases (PRMTs) with antitumour activity, inhibits PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, and increases the proliferative capacity of isolated cultured MuSC. It can be used to study breast cancer.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $77 | In Stock | |
10 mg | $108 | In Stock | |
25 mg | $179 | In Stock | |
50 mg | $266 | In Stock | |
100 mg | $395 | In Stock | |
1 mL x 10 mM (in DMSO) | $39 | In Stock |
Description | MS023 dihydrochloride (MS023 2HCl) is a selective, cytosolic and highly potent inhibitor of human type I protein arginine methyltransferases (PRMTs) with antitumour activity, inhibits PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, and increases the proliferative capacity of isolated cultured MuSC. It can be used to study breast cancer. |
In vitro | MS023 dihydrochloride (1-1000 nM) effectively and concentration-dependently reduces PRMT1 methyltransferase activity in MCF7 cells[1]. |
In vivo | In NOD-scid IL2Rgnull (NSG) mice bearing primary MLL-r ALL cells, combinatorial treatment with MS023 dihydrochloride (160 mg/kg, ip) and PKC412 (100 mg/kg, i.g.) for 4 weeks extended the survival of leukemic mice compared to single treatments[2]. |
Alias | MS023 2HCl |
Molecular Weight | 360.32 |
Formula | C17H27Cl2N3O |
Cas No. | 1992047-64-9 |
Smiles | Cl.Cl.CC(C)Oc1ccc(cc1)-c1c[nH]cc1CN(C)CCN |
Storage | store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 20 mg/mL (55.56 mM) DMSO: 100 mg/mL (277.78 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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