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N-Acetyl lysyltyrosylcysteine amide acetate
Catalog No. T38063L
Alias N-Acetyl lysyltyrosylcysteine amide acetate(1287585-40-3 Free base)
N-Acetyl lysyltyrosylcysteine amide acetate is an effective and selective tripeptide inhibitor of myeloperoxidase (MPO). N-Acetyl lysyltyrosylcysteine amide acetate inhibits MPO-dependent hypochlorous acid (HOCl) generation, protein nitration, and LDL ox
N-Acetyl lysyltyrosylcysteine amide acetate
Catalog No. T38063LAlias N-Acetyl lysyltyrosylcysteine amide acetate(1287585-40-3 Free base)
N-Acetyl lysyltyrosylcysteine amide acetate is an effective and selective tripeptide inhibitor of myeloperoxidase (MPO). N-Acetyl lysyltyrosylcysteine amide acetate inhibits MPO-dependent hypochlorous acid (HOCl) generation, protein nitration, and LDL ox
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $86 | Backorder | |
| 5 mg | $197 | Backorder | |
| 10 mg | $347 | Backorder | |
| 25 mg | $625 | Backorder | |
| 50 mg | $937 | Backorder | |
| 100 mg | $1,397 | Backorder | |
| 200 mg | $2,112 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | N-Acetyl lysyltyrosylcysteine amide acetate is an effective and selective tripeptide inhibitor of myeloperoxidase (MPO). N-Acetyl lysyltyrosylcysteine amide acetate inhibits MPO-dependent hypochlorous acid (HOCl) generation, protein nitration, and LDL ox |
| In vivo | N-Acetyl lysyltyrosylcysteine amide acetate (10 mg/kg; i.p.; daily 7 days) significantly protects BBB function and decreased neutrophil infiltration. N-Acetyl lysyltyrosylcysteine amide acetate (10 mg/kg; i.p.; daily 7 days) significantly reduces microglia/macrophage activation and neuron loss in MCAO mice. N-Acetyl lysyltyrosylcysteine amide acetate (10 mg/kg; i.p.; daily for 3-7 days) decreases apoptosis and cell injury in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide acetate reduced MPO in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide acetate reduces NO2Tyr and 4-HNE in MCAO mice. N-Acetyl lysyltyrosylcysteine amide acetate significantly decreases infarct size, blood-brain barrier leakage, infiltration of myeloid cells, loss of neurons, and apoptosis in the brains of middle cerebral artery occlusion (MCAO) mice. N-Acetyl lysyltyrosylcysteine amide acetate (10 mg/kg; i.p.; daily for 3-7 days) significantly reduces neurological severity scores and infarct size in MCAO mice[2]. |
| Alias | N-Acetyl lysyltyrosylcysteine amide acetate(1287585-40-3 Free base) |
| Molecular Weight | 513.61 |
| Formula | C22H35N5O7S |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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