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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $41 | In Stock | |
5 mg | $97 | In Stock | |
10 mg | $155 | In Stock | |
25 mg | $313 | In Stock | |
50 mg | $497 | In Stock | |
100 mg | $723 | In Stock | |
500 mg | $1,520 | In Stock | |
1 mL x 10 mM (in DMSO) | $107 | In Stock |
Description | N-Desmethyl Sildenafil is the major metabolite of Sildenafil, a potent phosphodiesterase type 5 (PDE5) inhibitor. |
In vitro | N-Desmethyl Sildenafil enhances the amplitude of electroretinogram (ERG) signals from dark-adapted isolated rat retinas, likely by improving photoreceptor cell responses[1]. This compound's formation is investigated through the use of CYP3A supersomes that co-express human P450 oxidoreductase and cytochrome b5, with its synthesis being predominantly catalyzed by CYP3A4 and CYP3A5 enzymes, and to a smaller degree by CYP3A7[2]. |
Alias | Desmethylsildenafil, UK-103,320 |
Molecular Weight | 460.55 |
Formula | C21H28N6O4S |
Cas No. | 139755-82-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMF: 5 mg/mL DMSO:PBS (pH 7.2)(1:5): 0.15 mg/mL DMSO: 225 mg/mL (488.5 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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