Powder: -20°C for 3 years | In solvent: -80°C for 1 year
N-Desmethyl Sildenafil (UK-103,320) (Desmethylsildenafil) is a prominent metabolite of Sildenafil, a potent inhibitor of phosphodiesterase type 5 (PDE5).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 41.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 155.00 | |
25 mg | In stock | $ 313.00 | |
50 mg | In stock | $ 497.00 | |
100 mg | In stock | $ 723.00 | |
500 mg | In stock | $ 1,520.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 107.00 |
Description | N-Desmethyl Sildenafil (UK-103,320) (Desmethylsildenafil) is a prominent metabolite of Sildenafil, a potent inhibitor of phosphodiesterase type 5 (PDE5). |
In vitro | N-Desmethyl Sildenafil enhances the amplitude of electroretinogram (ERG) signals from dark-adapted isolated rat retinas, likely by improving photoreceptor cell responses[1]. This compound's formation is investigated through the use of CYP3A supersomes that co-express human P450 oxidoreductase and cytochrome b5, with its synthesis being predominantly catalyzed by CYP3A4 and CYP3A5 enzymes, and to a smaller degree by CYP3A7[2]. |
Synonyms | Desmethylsildenafil, UK-103,320 |
Molecular Weight | 460.55 |
Formula | C21H28N6O4S |
CAS No. | 139755-82-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 5 mg/mL
DMSO:PBS (pH 7.2)(1:5): 0.15 mg/mL
DMSO: 225 mg/mL (488.5 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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N-Desmethyl Sildenafil 139755-82-1 Metabolism Drug Metabolite Desmethylsildenafil UK-103,320 inhibitor inhibit