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N-Desmethyl Sildenafil

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Purity:99.68%

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COA HNMR HPLC

N-Desmethyl Sildenafil

Catalog No. T36061Cas No. 139755-82-1

N-Desmethyl Sildenafil is the major metabolite of Sildenafil, a potent phosphodiesterase type 5 (PDE5) inhibitor.

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Pack Size	Price	Availability
1 mg	$41	In Stock
5 mg	$97	In Stock
10 mg	$155	In Stock
25 mg	$313	In Stock
50 mg	$497	In Stock
100 mg	$723	In Stock
500 mg	$1,520	In Stock
1 mL x 10 mM (in DMSO)	$107	In Stock

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Product Introduction

Bioactivity

Description	N-Desmethyl Sildenafil is the major metabolite of Sildenafil, a potent phosphodiesterase type 5 (PDE5) inhibitor.
In vitro	N-Desmethyl Sildenafil enhances the amplitude of electroretinogram (ERG) signals from dark-adapted isolated rat retinas, likely by improving photoreceptor cell responses[1]. This compound's formation is investigated through the use of CYP3A supersomes that co-express human P450 oxidoreductase and cytochrome b5, with its synthesis being predominantly catalyzed by CYP3A4 and CYP3A5 enzymes, and to a smaller degree by CYP3A7[2].
Alias	Desmethylsildenafil, UK-103,320

Chemical Properties

Molecular Weight	460.55
Formula	C21H28N6O4S
Cas No.	139755-82-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMF: 5 mg/mL

DMSO:PBS (pH 7.2)(1:5): 0.15 mg/mL

DMSO: 225 mg/mL (488.5 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1713 mL	10.8566 mL	21.7132 mL	108.5658 mL
5 mM	0.4343 mL	2.1713 mL	4.3426 mL	21.7132 mL
10 mM	0.2171 mL	1.0857 mL	2.1713 mL	10.8566 mL
20 mM	0.1086 mL	0.5428 mL	1.0857 mL	5.4283 mL
50 mM	0.0434 mL	0.2171 mL	0.4343 mL	2.1713 mL
100 mM	0.0217 mL	0.1086 mL	0.2171 mL	1.0857 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc