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N-Desmethyl Sildenafil
🥰Excellent
Catalog No. T36061Cas No. 139755-82-1
Alias UK-103,320, Desmethylsildenafil
N-Desmethyl Sildenafil is the major metabolite of Sildenafil, a potent phosphodiesterase type 5 (PDE5) inhibitor.
N-Desmethyl Sildenafil
🥰Excellent
Purity: 99.68%
Catalog No. T36061Alias UK-103,320, DesmethylsildenafilCas No. 139755-82-1
N-Desmethyl Sildenafil is the major metabolite of Sildenafil, a potent phosphodiesterase type 5 (PDE5) inhibitor.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $35 | In Stock | |
| 5 mg | $58 | In Stock | |
| 10 mg | $93 | In Stock | |
| 25 mg | $188 | In Stock | |
| 50 mg | $298 | In Stock | |
| 100 mg | $433 | In Stock | |
| 200 mg | $616 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $64 | In Stock |
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Purity:99.68%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | N-Desmethyl Sildenafil is the major metabolite of Sildenafil, a potent phosphodiesterase type 5 (PDE5) inhibitor. |
| In vitro | N-Desmethyl Sildenafil enhances the amplitude of electroretinogram (ERG) signals from dark-adapted isolated rat retinas, likely by improving photoreceptor cell responses[1]. This compound's formation is investigated through the use of CYP3A supersomes that co-express human P450 oxidoreductase and cytochrome b5, with its synthesis being predominantly catalyzed by CYP3A4 and CYP3A5 enzymes, and to a smaller degree by CYP3A7[2]. |
| Alias | UK-103,320, Desmethylsildenafil |
| Molecular Weight | 460.55 |
| Formula | C21H28N6O4S |
| Cas No. | 139755-82-1 |
| Smiles | CCCc1nn(C)c2c1[nH]c(nc2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCNCC1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMF: 5 mg/mL (10.86 mM), Sonication is recommended. DMSO:PBS (pH 7.2)(1:5): 0.15 mg/mL (0.33 mM), Sonication is recommended. DMSO: 225 mg/mL (488.5 mM), Sonication is recommended. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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