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N6-(2-Hydroxyethyl)adenosine, a Ca2+ antagonist and anti-inflammatory agent, is associated with the regulation of cerebral and coronary circulation and is believed to exhibit sedative activity.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 mg | $32 | In Stock | |
100 mg | $48 | In Stock | |
1 mL x 10 mM (in DMSO) | $45 | In Stock |
Description | N6-(2-Hydroxyethyl)adenosine, a Ca2+ antagonist and anti-inflammatory agent, is associated with the regulation of cerebral and coronary circulation and is believed to exhibit sedative activity. |
In vitro | N6-(2-Hydroxyethyl)adenosine can suppress TGF-β1 or LPS-induced TGF-β1/Smad and NF-κB signaling pathways in vitro. The levels of ECM production, indicated by expression of collagen I, α-SMA and Fibronectin, are significantly reduced by treatment with N6-(2-Hydroxyethyl)adenosine dose-dependently (5, 10, and 20 μg/ml). Similarly, TGF-β and LPS stimulate increased levels of TNF-α, IL-1β and IL-10. N6-(2-Hydroxyethyl)adenosine treatment reduces the elevated levels of TNF-α and IL-1β and increases IL-10 secretion dose-dependently [1]. |
In vivo | Injury of Kidney Tissue in UUO Mice Ameliorated by Intraperitoneal Administration of N6-(2-Hydroxyethyl) adenosine (2.5, 5, and 7.5 mg/kg; intraperitoneal injection). N6-(2-Hydroxyethyl) adenosine treatment prevents the accumulation of fibrosis-related proteins (TGF-β1, α-SMA, collagen I, and Fibronectin) and inflammatory cytokines (TNF-α, IL-6, IL-1β, and IL-10) associated with renal interstitial fibrosis. N6-(2-Hydroxyethyl) adenosine could block the accumulation of M1 macrophages, and induced the accumulation of M2 macrophages in ligated kidneys [1]. |
Molecular Weight | 311.29 |
Formula | C12H17N5O5 |
Cas No. | 4338-48-1 |
Smiles | OCCNc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 4.8 mg/mL (15.42 mM), Sonication is recommended. ![]() | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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