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N6-(2-Hydroxyethyl)adenosine

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Catalog No. TNU0429Cas No. 4338-48-1

N6-(2-Hydroxyethyl)adenosine, a Ca2+ antagonist and anti-inflammatory agent, is associated with the regulation of cerebral and coronary circulation and is believed to exhibit sedative activity.

N6-(2-Hydroxyethyl)adenosine

N6-(2-Hydroxyethyl)adenosine

🥰Excellent
Purity: 99.4%
Catalog No. TNU0429Cas No. 4338-48-1
N6-(2-Hydroxyethyl)adenosine, a Ca2+ antagonist and anti-inflammatory agent, is associated with the regulation of cerebral and coronary circulation and is believed to exhibit sedative activity.
Pack SizePriceAvailabilityQuantity
50 mg$32 In Stock
100 mg$48 In Stock
1 mL x 10 mM (in DMSO)$45 In Stock
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Purity:99.4%
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Product Introduction

Bioactivity
Description
N6-(2-Hydroxyethyl)adenosine, a Ca2+ antagonist and anti-inflammatory agent, is associated with the regulation of cerebral and coronary circulation and is believed to exhibit sedative activity.
In vitro
N6-(2-Hydroxyethyl)adenosine can suppress TGF-β1 or LPS-induced TGF-β1/Smad and NF-κB signaling pathways in vitro. The levels of ECM production, indicated by expression of collagen I, α-SMA and Fibronectin, are significantly reduced by treatment with N6-(2-Hydroxyethyl)adenosine dose-dependently (5, 10, and 20 μg/ml). Similarly, TGF-β and LPS stimulate increased levels of TNF-α, IL-1β and IL-10. N6-(2-Hydroxyethyl)adenosine treatment reduces the elevated levels of TNF-α and IL-1β and increases IL-10 secretion dose-dependently [1].
In vivo
Injury of Kidney Tissue in UUO Mice Ameliorated by Intraperitoneal Administration of N6-(2-Hydroxyethyl) adenosine (2.5, 5, and 7.5 mg/kg; intraperitoneal injection). N6-(2-Hydroxyethyl) adenosine treatment prevents the accumulation of fibrosis-related proteins (TGF-β1, α-SMA, collagen I, and Fibronectin) and inflammatory cytokines (TNF-α, IL-6, IL-1β, and IL-10) associated with renal interstitial fibrosis. N6-(2-Hydroxyethyl) adenosine could block the accumulation of M1 macrophages, and induced the accumulation of M2 macrophages in ligated kidneys [1].
Chemical Properties
Molecular Weight311.29
FormulaC12H17N5O5
Cas No.4338-48-1
SmilesOCCNc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 4.8 mg/mL (15.42 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.2124 mL16.0622 mL32.1244 mL160.6219 mL
5 mM0.6425 mL3.2124 mL6.4249 mL32.1244 mL
10 mM0.3212 mL1.6062 mL3.2124 mL16.0622 mL

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