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Naratuximab emtansine
Catalog No. T9901A-223Cas No. 1607824-64-5
Alias IMGN529, Debio 1562
Naratuximab emtansine (IMGN529) is a CD37-targeted antibody-drug conjugate (ADC) composed of a humanized IgG1 monoclonal antibody linked to the microtubule-disrupting agent DM1. This compound demonstrates high affinity and specificity to CD37, facilitating the internalization, processing, and intracellular release of DM1. The functional activity of DM1 enables it to induce cell cycle arrest and apoptosis by disrupting microtubule assembly.
Naratuximab emtansine
Naratuximab emtansine
Catalog No. T9901A-223Alias IMGN529, Debio 1562Cas No. 1607824-64-5
Naratuximab emtansine (IMGN529) is a CD37-targeted antibody-drug conjugate (ADC) composed of a humanized IgG1 monoclonal antibody linked to the microtubule-disrupting agent DM1. This compound demonstrates high affinity and specificity to CD37, facilitating the internalization, processing, and intracellular release of DM1. The functional activity of DM1 enables it to induce cell cycle arrest and apoptosis by disrupting microtubule assembly.
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| 5 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Naratuximab emtansine (IMGN529) is a CD37-targeted antibody-drug conjugate (ADC) composed of a humanized IgG1 monoclonal antibody linked to the microtubule-disrupting agent DM1. This compound demonstrates high affinity and specificity to CD37, facilitating the internalization, processing, and intracellular release of DM1. The functional activity of DM1 enables it to induce cell cycle arrest and apoptosis by disrupting microtubule assembly. |
| In vitro | Naratuximab emtansine (IMGN529) (0.125 nM, 24 h) administered alone can induce activation of caspases 3/7 in DLBCL cell lines, an effect significantly enhanced by the presence of rituximab (2 nM), which further induces an increase in cleaved PARP levels. Additionally, Naratuximab emtansine (IMGN529) (0-3 ng/mL) demonstrates dose-dependent antibody-dependent cell-mediated cytotoxicity (ADCC) activity in U-2932 and SU-DHL-4 cell lines. |
| In vivo | A single treatment of Naratuximab emtansine (IMGN529) at a dosage of 10 mg/kg (administered as a one-time injection) showed no activity against U-2932 tumors alone. However, when combined with rituximab, there was a significant enhancement in antitumor activity. Throughout the study, no noticeable toxicity or weight loss was observed in female U2932 CB.17-SCID mice. |
| Alias | IMGN529, Debio 1562 |
| Cas No. | 1607824-64-5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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