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Narlaprevir
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Catalog No. T16274Cas No. 865466-24-6
Alias SCH900518, SCH 900518
Narlaprevir (SCH 900518) is an orally active, selective, and potent hepatitis C virus nonstructural protein 3 (HCV NS3) inhibitor, with antiviral activity against HCV and inhibition of SARS-CoV-2, used for studying viral infections.
Narlaprevir
😃Good
Catalog No. T16274Alias SCH900518, SCH 900518Cas No. 865466-24-6
Narlaprevir (SCH 900518) is an orally active, selective, and potent hepatitis C virus nonstructural protein 3 (HCV NS3) inhibitor, with antiviral activity against HCV and inhibition of SARS-CoV-2, used for studying viral infections.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $458 | In Stock | |
| 25 mg | Inquiry | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Narlaprevir (SCH 900518) is an orally active, selective, and potent hepatitis C virus nonstructural protein 3 (HCV NS3) inhibitor, with antiviral activity against HCV and inhibition of SARS-CoV-2, used for studying viral infections. |
| Targets&IC50 | Ketoamide:7 nM (Ki), NS3 protease:40 nM (EC90), NS3 protease:6 nM (Ki), Replicon RNA:40 nM (EC90) |
| In vitro | Narlaprevir is a selective NS3 protease inhibitor with a Ki of 6 nM and an EC90 of 40 nM. Narlaprevir is also an inhibitor of SARS-CoV 3CLpro with an IC50 of 2.3 μM. [1] [2] |
| In vivo | Narlaprevir rats, when administered orally, showed a very good AUC of 6.5 μM·h and a bioavailability of 46%. It is well distributed in target organs. The liver concentration of rats was 750 ng/g at 8 hours (C8h) after administration. [1] |
| Alias | SCH900518, SCH 900518 |
| Molecular Weight | 707.96 |
| Formula | C36H61N5O7S |
| Cas No. | 865466-24-6 |
| Smiles | C(N[C@H](C(C(NC1CC1)=O)=O)CCCC)(=O)[C@@H]2[C@@]3([C@@](C3(C)C)(CN2C([C@@H](NC(NC4(CS(C(C)(C)C)(=O)=O)CCCCC4)=O)[C@](C)(C)C)=O)[H])[H] |
| Relative Density. | 1.21 g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: < 1 mg/mL (insoluble) DMSO: 40 mg/mL (56.5 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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