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Narlaprevir

Name: Narlaprevir
Brand: TargetMol
SKU: T16274
Price: 135 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T16274Cas No. 865466-24-6

Alias SCH 900518

Narlaprevir is an effective, selective, and orally bioavailable NS3 protease inhibitor(Ki=6 nM; EC90=40 nM).

Narlaprevir

😃Good

Catalog No. T16274Alias SCH 900518Cas No. 865466-24-6

Narlaprevir is an effective, selective, and orally bioavailable NS3 protease inhibitor(Ki=6 nM; EC90=40 nM).

Pack Size	Price	Availability	Quantity
2 mg	198 €	5 days
25 mg	Inquiry	10-14 weeks

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Product Introduction

Bioactivity

Description	Narlaprevir is an effective, selective, and orally bioavailable NS3 protease inhibitor(Ki=6 nM; EC90=40 nM).
Targets&IC50	Ketoamide:7 nM (Ki), NS3 protease:40 nM (EC90), NS3 protease:6 nM (Ki), Replicon RNA:40 nM (EC90)
In vitro	Narlaprevir administration resulted in a robust HCV-RNA decline and high SVR rates when followed by standard of care in both treatment-experienced and treatment-naive HCV genotype 1-infected patients. HCV Narlaprevir is a potent inhibitor of the hepatitis C virus (HCV) nonstructural protein 3 serine protease that is primarily metabolized by the cytochrome P450-3A4 system.
Alias	SCH 900518

Chemical Properties

Molecular Weight	707.96
Formula	C₃₆H₆₁N₅O₇S
Cas No.	865466-24-6
Relative Density.	1.21 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 50 mg/mL (70.63 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4125 mL	7.0625 mL	14.1251 mL	70.6255 mL
5 mM	0.2825 mL	1.4125 mL	2.8250 mL	14.1251 mL
10 mM	0.1413 mL	0.7063 mL	1.4125 mL	7.0625 mL
20 mM	0.0706 mL	0.3531 mL	0.7063 mL	3.5313 mL
50 mM	0.0283 mL	0.1413 mL	0.2825 mL	1.4125 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

NarlaprevirSCH-900518SCH900518