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NDBM

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Catalog No. T79556

NDBM, a tumor-specific probe that targets Pim-1 kinase, exhibits heightened fluorescence upon binding and induces cytotoxicity, facilitating both cell screening and killing. It possesses targeted action on lysosomes and a sensitive pH response, enabling the monitoring of intracellular pH variations associated with autophagy and external stimuli [1].

NDBM

NDBM

😃Good
Catalog No. T79556
NDBM, a tumor-specific probe that targets Pim-1 kinase, exhibits heightened fluorescence upon binding and induces cytotoxicity, facilitating both cell screening and killing. It possesses targeted action on lysosomes and a sensitive pH response, enabling the monitoring of intracellular pH variations associated with autophagy and external stimuli [1].
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Product Introduction

Bioactivity
Description
NDBM, a tumor-specific probe that targets Pim-1 kinase, exhibits heightened fluorescence upon binding and induces cytotoxicity, facilitating both cell screening and killing. It possesses targeted action on lysosomes and a sensitive pH response, enabling the monitoring of intracellular pH variations associated with autophagy and external stimuli [1].
In vivo
NDBM exhibits lower fluorescence intensity in normal cells (HUVEC, RAW 264.7 cell lines) compared to tumor cells (MGC-803, HepG2, and Hela cell lines) [1]. At concentrations of 2.5, 5, 10, and 20 μM over 18 hours, NDBM reduces the viability of tumor cells (MGC-803, HepG2, and Hela) [1].
Chemical Properties
Molecular Weight679.56
FormulaC33H35BrN4O7
Storage & Solubility Information
StorageShipping with blue ice.

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