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Nicotinamide Riboside Triflate

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Nicotinamide Riboside Triflate

Catalog No. T33663Cas No. 445489-49-6

Nicotinamide Riboside Triflate (SRT647 Triflate) is a natural NAD precursor that increases NAD levels, enhances oxidative metabolism and prevents obesity induced by a high-fat diet+, and can be used in studies of muscle atrophy.

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25 mg	$4,498	Backorder

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Product Introduction

Bioactivity

Description	Nicotinamide Riboside Triflate (SRT647 Triflate) is a natural NAD precursor that increases NAD levels, enhances oxidative metabolism and prevents obesity induced by a high-fat diet+, and can be used in studies of muscle atrophy.
In vitro	Nicotinamide Riboside Triflate (1-1000 μM; HEK293T cells) exhibits a concentration-dependent increase in intracellular and mitochondrial NAD+ content in C2C12, Hepa1.6, and HEK293 cells.[1] Nicotinamide Riboside Triflate (0.5 nM; 24 h; HEK293T cells) reduces the acetylation status of Ndufa9 and SOD2.[1] Nicotinamide Riboside Triflate enhances NAD levels to reinstate the antiviral poly(ADP-ribose) polymerase (PARP) functions, bolstering innate immunity against coronaviruses (CoVs), a contributing factor to COVID-19.[3]
In vivo	Nicotinamide Riboside Triflate (400 mg/kg/day; p.o.; for 16 weeks; 10-week-old C57Bl/6J mice) results in tissue-specific increases in both plasma and intracellular NAD+ levels.[1]
Alias	SRT 647 Triflate, SRT 647, Nicotinamide Riboside, Nicotinamide Ribose, SRT-647, SRT647, SRT647 Triflate, SRT-647 Triflate

Chemical Properties

Molecular Weight	404.32
Formula	C12H15F3N2O8S
Cas No.	445489-49-6

Storage & Solubility Information

Storage

store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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