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Nomegestrol
Catalog No. T19811Cas No. 58691-88-6
Alias TX 066 free base
Nomegestrol (TX 066 free base) is an orally available, selective and potent full agonist of the progesterone receptor with potent anti-estrogenic, partial anti-androgenic and anti-gonadotropic activity.Nomegestrol is also a contraceptive progestin and is used in the study of endometriosis and meningiomas.
Nomegestrol
Catalog No. T19811Alias TX 066 free baseCas No. 58691-88-6
Nomegestrol (TX 066 free base) is an orally available, selective and potent full agonist of the progesterone receptor with potent anti-estrogenic, partial anti-androgenic and anti-gonadotropic activity.Nomegestrol is also a contraceptive progestin and is used in the study of endometriosis and meningiomas.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $208 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Nomegestrol (TX 066 free base) is an orally available, selective and potent full agonist of the progesterone receptor with potent anti-estrogenic, partial anti-androgenic and anti-gonadotropic activity.Nomegestrol is also a contraceptive progestin and is used in the study of endometriosis and meningiomas. |
| Targets&IC50 | uterine progesterone receptor (rat):5.44 nM (Kd) |
| In vitro | Nomegestrol is a highly selective full agonist at the progesterone receptor but has little or no binding affinity for other steroid receptors such as the androgen and glucocorticoid receptors. [1] Nomegestrol is a progestin with a high binding affinity for the progesterone receptor and a Kd of 5.44 nM for the rat uterine progesterone receptor. [2] |
| In vivo | In animal models, Nomegestrol demonstrated moderate antiandrogenic activity and strong antiestrogenic activity. [1] |
| Alias | TX 066 free base |
| Molecular Weight | 328.45 |
| Formula | C21H28O3 |
| Cas No. | 58691-88-6 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 8 mg/mL (24.36 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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