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Levonorgestrel
Catalog No. T1263Cas No. 797-63-7
Alias D-Norgestrel
Levonorgestrel (D-Norgestrel) is a Progestin and Progestin-containing Intrauterine Device. The physiologic effect of levonorgestrel is by means of Inhibit Ovum Fertilization.
Levonorgestrel
Catalog No. T1263Alias D-NorgestrelCas No. 797-63-7
Levonorgestrel (D-Norgestrel) is a Progestin and Progestin-containing Intrauterine Device. The physiologic effect of levonorgestrel is by means of Inhibit Ovum Fertilization.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 mg | $42 | In Stock | |
| 200 mg | $47 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $46 | In Stock |
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Purity:99.83%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Levonorgestrel (D-Norgestrel) is a Progestin and Progestin-containing Intrauterine Device. The physiologic effect of levonorgestrel is by means of Inhibit Ovum Fertilization. |
| In vitro | Levonorgestrel significantly upregulates mRNA expression of the gene encoding luteinizing hormone beta subunit (lhβ) in both male and female cockroaches, while downregulating mRNA expression of the gene encoding follicle-stimulating hormone beta subunit (fshβ). Furthermore, in long-clawed ground squirrels, Levonorgestrel decreases the mRNA expression of ovarian follicle-stimulating hormone receptor, luteinizing hormone receptor, ovarian estrogen receptor β, and progesterone receptor, as well as the mRNA expression of ERα and PR in the uterus. |
| In vivo | Levonorgestrel elevates cyclic AMP levels in the veins and inhibits the activation of protein kinase C induced by PMA. It suppresses progesterone secretion in rat luteal cells, which is stimulated by oLH, dibutyryl-cAMP, and pregnenolone. Levonorgestrel also inhibits contractions induced by high potassium (K(+)) solutions or PMA in the presence and absence of extracellular calcium (Ca(2+)), effectuating endothelium-dependent relaxation through hindrance of calcium ion ingress and protein kinase C activation. Moreover, while the inhibitory effects of Levonorgestrel on estrogen-induced pituitary weight gain and hyperprolactinemia are attenuated by mifepristone, flunarizine does not block its effects. |
| Alias | D-Norgestrel |
| Molecular Weight | 312.45 |
| Formula | C21H28O2 |
| Cas No. | 797-63-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 16.67 mg/mL (53.34 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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