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NQTrp
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Catalog No. T22118Cas No. 185351-19-3
NQTrp is an inhibitor of the aggregation of the tau protein with generic anti-amyloidogenic effects.
NQTrp
😃Good
Catalog No. T22118Cas No. 185351-19-3
NQTrp is an inhibitor of the aggregation of the tau protein with generic anti-amyloidogenic effects.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $35 | 5 days | |
| 5 mg | $73 | 7-10 days | |
| 10 mg | $113 | 7-10 days | |
| 25 mg | $198 | 7-10 days | |
| 50 mg | $293 | 7-10 days | |
| 100 mg | $433 | 7-10 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | NQTrp is an inhibitor of the aggregation of the tau protein with generic anti-amyloidogenic effects. |
| In vitro | NQTrp inhibits the in vitro aggregation of hexapeptide (41GCWMLY46 within the N-terminus of γD-crystallin) as well as full-length γD-crystallin. NQTrp effectively inhibits the fibrillation of the GDC6 peptide (50 μM) in a dose-dependent manner and prevents the formation of elongated amyloid fibrils[1]. NQTrp has no toxic effect toward retinal cell culture and reduces the cytotoxicity induced by aggregates of the hexapeptide(IC50=70 μM) in ARPE-19 cells. In TEM analysis, GDC6 peptide fibrils (50 μM) in the presence of NQTrp 5:1, 1:1, 1:5 ratio (GDC6: NQTrp)[1]. |
| Molecular Weight | 360.36 |
| Formula | C21H16N2O4 |
| Cas No. | 185351-19-3 |
| Relative Density. | 1.45 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 125 mg/mL (346.88 mM), Sonication and heating to 60℃ are recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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