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NS-3-008 hydrochloride

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Purity:98.68%

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COA HNMR HPLC

NS-3-008 hydrochloride

Catalog No. T8494Cas No. 1172854-54-4

NS-3-008 hydrochloride (NS-3-008 HCl) is a transcriptional G0/G1 switch 2 (G0s2) inhibitor( IC50 of 2.25 μM).

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Pack Size	Price	Availability
1 mg	$30	In Stock
2 mg	$40	In Stock
5 mg	$64	In Stock
10 mg	$97	In Stock
25 mg	$176	In Stock
50 mg	$296	In Stock
100 mg	$443	In Stock
1 mL x 10 mM (in DMSO)	$84	In Stock

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Product Introduction

Bioactivity

Description	NS-3-008 hydrochloride (NS-3-008 HCl) is a transcriptional G0/G1 switch 2 (G0s2) inhibitor( IC50 of 2.25 μM).
In vivo	Administration of NS-3-008 inhibited the expression of G0s2 in healthy mice liver.?In contrast, administration of NS-3-008 did not affect the MBP in wild-type sham and 5/6Nx mice.?NS-3-008 as a novel G0s2 inhibitor and showed that administration of this inhibitor ameliorated renal dysfunction in wild-type 5/6Nx mice.
Alias	NS-3-008 HCl

Chemical Properties

Molecular Weight	269.81
Formula	C14H24ClN3
Cas No.	1172854-54-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 120 mg/mL(444.76 mM)

H2O: 125 mg/mL (463.29 mM)

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7063 mL	18.5316 mL	37.0631 mL	185.3156 mL
5 mM	0.7413 mL	3.7063 mL	7.4126 mL	37.0631 mL
10 mM	0.3706 mL	1.8532 mL	3.7063 mL	18.5316 mL
20 mM	0.1853 mL	0.9266 mL	1.8532 mL	9.2658 mL
50 mM	0.0741 mL	0.3706 mL	0.7413 mL	3.7063 mL
100 mM	0.0371 mL	0.1853 mL	0.3706 mL	1.8532 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

renalinhibitCcl2NS3008 hydrochlorideHsd17b4Stat5transcriptionalInhibitorNS-3-008 HydrochloridedysfunctionameliorateCKDNS 3 008 hydrochloridep65G0s2