p65

PTD-p65-P1 Peptide, a selective inhibitor of the nuclear transcription factor NF-kappaB, consists of a conjugation between a membrane-translocating peptide derived from antennapedia (PTD) and p65-P1. This composition effectively inhibits activation triggered by diverse inflammatory stimuli.

Ptd-p65-p1 Peptide TFA is a nuclear transcription factor nf-kappab inhibitor, consisting of a membrane transport Peptide sequence derived from antennapedia linked to p65-p1, selectively inhibiting nf-kappab activity induced by various stimuli.

CMV pp65(13-27) is a bioactive peptide derived from the 65k lower matrix phosphoprotein of the human cytomegalovirus, specifically comprising amino acid residues 13 to 27. It includes a nine-amino-acid sequence (LGPISGHVL) that corresponds to the consensus binding motif for the major histocompatibility complex H2-Dd T-cell epitope.

F1, an anti-inflammatory peptide, incorporates the HIV-1 Tat protein transduction domain linked with a 15-amino acid sequence from residues 46-60 of the inhibitor of NF-κB kinase-interacting peptide (IKIP). It effectively blocks LPS-induced phosphorylation of IκB kinase α (IKKα) and IKKβ, along with the nuclear translocation of NF-κB (p65) in mouse peritoneal macrophages at 5 µM concentration. F1, administered at 5 mg/kg in vivo, significantly reduces IL-6, TNF-α, and IL-1β serum levels and enhances survival in a mouse sepsis model induced by LPS.