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OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $32 | In Stock | |
5 mg | $72 | In Stock | |
10 mg | $132 | In Stock | |
25 mg | $267 | In Stock | |
50 mg | $428 | In Stock | |
100 mg | $662 | In Stock | |
200 mg | $926 | In Stock | |
1 mL x 10 mM (in DMSO) | $72 | In Stock |
Description | OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain. |
Targets&IC50 | BRPF2:500 nM(Kd), BRPF1B:100 nM(Kd) |
In vitro | As a chemical probe for BRPF bromodomains, OF-1 increases thermal stability in the cellular thermal shift assay of full length BRPF1B at 1 μM and also demonstrates accelerated FRAP recovery at 5 μM in the BRPF2 FRAP assay. In addition, OF-1 shows modest general cytotoxicity. [1] |
Molecular Weight | 440.31 |
Formula | C17H18BrN3O4S |
Cas No. | 919973-83-4 |
Smiles | COc1cc2n(C)c(=O)n(C)c2cc1NS(=O)(=O)c1ccc(Br)cc1C |
Relative Density. | 1.557 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 8.8 mg/mL (20 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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