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OTUB2-IN-1
Catalog No. T87947
OTUB2-IN-1 is a selective OTUB2 inhibitor with anti-tumor activity that inhibits the expression of PD-L1 protein in tumor cells and inhibits tumor growth, and can be used to study skin cancer and non-small cell lung cancer (NSCLC).
OTUB2-IN-1
Catalog No. T87947
OTUB2-IN-1 is a selective OTUB2 inhibitor with anti-tumor activity that inhibits the expression of PD-L1 protein in tumor cells and inhibits tumor growth, and can be used to study skin cancer and non-small cell lung cancer (NSCLC).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $195 | In Stock | |
| 5 mg | $483 | In Stock | |
| 10 mg | $692 | In Stock | |
| 25 mg | $1,080 | In Stock | |
| 50 mg | $1,490 | In Stock | |
| 100 mg | $1,970 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | OTUB2-IN-1 is a selective OTUB2 inhibitor with anti-tumor activity that inhibits the expression of PD-L1 protein in tumor cells and inhibits tumor growth, and can be used to study skin cancer and non-small cell lung cancer (NSCLC). |
| In vitro | Incubation of recombinant GST-OTUB2 protein with OTUB2-IN-1 resulted in significant inhibition of Ub-R110 cleavage by GST-OTUB2 in a dose-dependent manner, suggesting that OTUB2-IN-1 can inhibit the hydrolytic activity of recombinant GST-OTUB2 protein toward its substrate Ub-R110 in vitro. [1] |
| In vivo | Evaluated the therapeutic potential of OTUB2-IN-1 using a mouse LL/2 tumor model. OTUB2-IN-1 treatment significantly suppressed tumor growth and prolonged mouse survival, and no obvious toxicity was observed. To clarify the effect of OTUB2-IN-1 in tumor inhibition through regulation of PD-L1 in vivo, LL/2 cells with stably expressed PD-L1 and control plasmids were used to establish a tumor model. As expected, in comparison to the control group, overexpressed PD-L1 resulted in a substantial increase in tumor growth, whereas OTUB2-IN-1 significantly reduced the PD-L1-overexpressing tumor growth. [1] |
| Molecular Weight | 434.49 |
| Formula | C19H18N2O6S2 |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (92.06 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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