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Oxyphenbutazone is an active metabolite of Phenylbutazone, an orally active COX inhibitor with antimicrobial and anti-inflammatory activity, selectively kills non-replicating Mycobacterium tuberculosis, and induces bone marrow failure.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $45 | In Stock | |
5 mg | $72 | In Stock | |
10 mg | $108 | In Stock | |
25 mg | $183 | In Stock | |
50 mg | $275 | In Stock | |
100 mg | $413 | In Stock | |
1 mL x 10 mM (in DMSO) | $119 | In Stock |
Description | Oxyphenbutazone is an active metabolite of Phenylbutazone, an orally active COX inhibitor with antimicrobial and anti-inflammatory activity, selectively kills non-replicating Mycobacterium tuberculosis, and induces bone marrow failure. |
In vitro | Oxyphenbutazone enhances the anticancer effect of methotrexate (MTX) in Hep3B cells with hepatocyte repair. In Hep3B cells, 2.5-7.5 µM Oxyphenbutazone, treated for 48 hours, exhibited significant cytotoxicity when combined with MTX (0.25-1.0 µM). [1] |
In vivo | In combination with MTX (5.0 or 2.5 mg/kg/week , intraperitoneal injection), Oxyphenbutazone (70 mg/kg/week, orally, in two divided doses, for 13 weeks of treatment) showed potential anticancer activity. [1] |
Molecular Weight | 324.37 |
Formula | C19H20N2O3 |
Cas No. | 129-20-4 |
Smiles | O=C1N(C=2C=CC=CC2)N(C3=CC=C(O)C=C3)C(=O)C1CCCC |
Relative Density. | 1.241g/cm3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (246.63 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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