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PARP-1-IN-4
🥰Excellent
Catalog No. T78182Cas No. 684234-56-8
PARP-1-IN-4 is a potent PARP-1 inhibitor with potential anti-tumor activity, where inhibition of PARP-1 may be applied in cancer treatment.
PARP-1-IN-4
🥰Excellent
Purity: 99.82%
Catalog No. T78182Cas No. 684234-56-8
PARP-1-IN-4 is a potent PARP-1 inhibitor with potential anti-tumor activity, where inhibition of PARP-1 may be applied in cancer treatment.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $39 | In Stock | |
| 10 mg | $64 | In Stock | |
| 25 mg | $128 | In Stock | |
| 50 mg | $213 | In Stock | |
| 100 mg | $318 | In Stock |
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Purity:99.82%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PARP-1-IN-4 is a potent PARP-1 inhibitor with potential anti-tumor activity, where inhibition of PARP-1 may be applied in cancer treatment. |
| Targets&IC50 | PARP1:302 μM |
| In vitro | PARP-1-IN-4 exhibits inhibitory activity against PARP-1, with an IC50 value of 302 μM[1]. It demonstrates cytotoxicity against A549 cells at concentrations of 0.1, 1, and 10 μM for 24h and 48h[1]. Treatment with PARP-1-IN-4 at 1 μM for 24h significantly increases the expression levels of caspase-3 and caspase-9 proteins[1]. |
| Molecular Weight | 424.28 |
| Formula | C22H15Cl2N3O2 |
| Cas No. | 684234-56-8 |
| Smiles | O=C(NC1=CC=C(Cl)C=C1)CN2N=C(C=3C=CC(Cl)=CC3)C=4C=CC=CC4C2=O |
Storage & Solubility Information
| Storage | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (11.78 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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