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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $39 | In Stock | |
10 mg | $64 | In Stock | |
25 mg | $128 | In Stock | |
50 mg | $213 | In Stock | |
100 mg | $318 | In Stock |
Description | PARP-1-IN-4 is a potent PARP-1 inhibitor with potential see anti-tumor activity, and inhibition of PARP-1 may be used in cancer development. |
In vitro | PARP-1-IN-4 exhibits inhibitory activity against PARP-1, with an IC50 value of 302 μM[1]. It demonstrates cytotoxicity against A549 cells at concentrations of 0.1, 1, and 10 μM for 24h and 48h[1]. Treatment with PARP-1-IN-4 at 1 μM for 24h significantly increases the expression levels of caspase-3 and caspase-9 proteins[1]. |
Molecular Weight | 424.28 |
Formula | C22H15Cl2N3O2 |
Cas No. | 684234-56-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||
Solubility Information | DMSO: 5 mg/mL (11.78 mM) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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