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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $39 | In Stock | |
10 mg | $64 | In Stock | |
25 mg | $123 | In Stock | |
50 mg | $228 | In Stock | |
100 mg | $372 | In Stock | |
200 mg | $517 | In Stock | |
1 mL x 10 mM (in DMSO) | $43 | In Stock |
Description | PFM01 is an inhibitor of MRE11 endonuclease. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR). |
In vitro | PFM01 (100 μM) treatment allows normal DSB repair in HR-defective ATMi-treated or HSC62 (BRCA2-defective) cells[1]. RAD51 foci did not form following exo- or endo-inhibitor treatment (mirin or PFM01) in 1BR3 (WT) and HSC62 (BRCA2-defective) cells[1]. PFM01 (100 μM) enhances non-homologous end-joining (NHEJ) in H1299 dA3 cells and reduces homologous recombination (HR) in U2OS DR-GFP cells[1]. PFM01 substantially relieves the double-strand break (DSB) repair defect confers by mirin or PFM39 in irradiated G2 cells[1]. |
Molecular Weight | 293.4 |
Formula | C14H15NO2S2 |
Cas No. | 1558598-41-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 4 mg/mL (13.63 mM) ![]() | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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