n-alkylated

[DPro10] Dynorphin A (1-11)acetate,porcine is a highly potent κ-opioid receptor agonist with a Ki value of 0.13 nM. [DPro10] Dynorphin A (1-11), porcine is an n-alkylated derivative with analgesic activity.

PFM01 is an inhibitor of MRE11 endonuclease. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR).

3'-Deoxy-N1-Methyl inosine is a Nucleoside Derivative - 3'-Modified nucleoside, N-Methylated/ alkylated nucleoside;3'-Deoxy nucleoside.

Nucleoside Derivatives - Xylo-nucleosides; 8-Modified purine nucleosides; Amino nucleosides; N-Methylated alkylated nucleosides

3',5'-Di-O-acetyl-2'-deoxy-5,N3-dimethyl uridine is a Nucleoside Derivative - N-Alkylated nucleoside.

Nucleoside Derivatives - Fluoro-modified nucleosides; N-Methylated alkylated nucleosides

N1-Methyl-2'-O-(2-methoxyethyl) adenosine is a Nucleoside Derivative - 2'-Modified nucleoside, N-Methylated/ alkylated nucleoside.

Nucleoside Derivatives - C-nucleosides; N-Methylated alkylated nucleosides

Nucleoside Derivatives - C-Nucleosides; Fluoro-modified nucleosides; N-Alkylated nucleosides

Nucleoside Derivatives - 3’-Modified nucleosides, Fluoro-modified nucleosides, N-Methylated/ alkylated nucleosides

N1-Methyl-2'-beta-C-methyl guanosine is a Nucleoside Derivative - 2'-Modified nucleoside, N-Methylated/ alkylated nucleoside.

3'-Deoxy-N1-methyladenosine is a Nucleoside Derivative - 3'-Modified nucleoside, N-Methylated/ alkylated nucleoside;3'-Deoxy nucleoside.

S2116 is a powerful inhibitor of lysine-specific demethylase 1 (LSD1), and it is a derivative of N-alkylated tranylcypromine (TCP). S2116 exhibits its inhibitory effects by increasing H3K9 methylation and inducing reciprocal H3K27 deacetylation at super-enhancer regions. In TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells, S2116 triggers apoptosis by repressing the transcription of NOTCH3 and TAL1 genes. Furthermore, S2116 demonstrates significant growth retardation of T-ALL cells when xenotransplanted into mice.

N1-Methyl-2'-O-(2-methoxyethyl) guanosine is a Nucleoside Derivative - 2'-Modified nucleoside, N-Methylated/ alkylated nucleoside.

Nucleoside Derivatives - 2’-Modified nucleosides; N-Alkylated nucleosides; Naturally modified ribo-nucleosides

2'-Deoxy-2'-fluoro-ara-uridine is a Nucleoside Derivative - 2'-Modified nucleoside, Fluoro-modified nucleoside, N-Methylated/ alkylated nucleoside.

7-Ethyl-7,8-dihydro-8-oxo-9-(beta-D-xylofuranosyl)guanine is a nucleoside derivative (xylo-nucleoside), specifically an N-methylated alkylated nucleoside and an 8-modified purine nucleoside.

7-n-Butyl-7,8-dihydro-8-oxo-9-(beta-D-xylofuranosyl)guanine is a nucleoside derivative (xylo-nucleoside), N-methylated alkylated nucleoside, and 8-modified purine nucleoside.

N1-Methyl-2'-O-(2-methoxyethyl) inosine is a Nucleoside Derivative - 2'-Modified nucleoside, N-Methylated/ alkylated nucleoside.

N1-Methyl-N3-[(2S)-2-(t-butoxycarbonyl)amino-3-(t-butoxycarbonyl)] propylpseudouridine is a nucleoside derivative categorized as a C-nucleoside and an N-alkylated nucleoside.

Nucleoside Derivatives - 8-Modified purine nucleosides; N-Methylated alkylated nucleosides

7-(Butyn-2-yl)-7,8-dihydro-8-oxo-9-(beta-D-xylofuranosyl)guanine is a nucleoside derivative (xylo-nucleoside), N-methylated alkylated nucleoside, and 8-modified purine nucleoside.

N1-Methyl-2'-beta-C-methyl inosine is a Nucleoside Derivative - 2'-Modified nucleoside; N-Methylated alkylated nucleoside.

3',5'-Di-O-acetyl-2'-deoxy-N3-methyl uridine is a Nucleoside Derivative - N-Alkylated nucleoside.

3'-Deoxy-N1-methylguanosine is a Nucleoside Derivative - 3'-Modified nucleoside, N-Methylated/ alkylated nucleoside;3'-Deoxy nucleoside.

Nucleoside Derivatives - Xylo-nucleosides; 8-Modified purine nucleosides; N-Methylated alkylated nucleosides

N1-Methyl-2'-deoxyinosine is a Nucleoside Derivative - N-Alkylated nucleoside.

3'-Deoxy-N7-methylguanosine is a Nucleoside Derivative - 3'-Modified nucleoside, N-Methylated/ alkylated nucleoside;3'-Deoxy nucleoside.

7-Propargyl-7,8-dihydro-8-oxo-9-(beta-D-xylofuranosyl)guanine is a nucleoside derivative categorized as a xylo-nucleoside, N-methylated alkylated nucleoside, and 8-modified purine nucleoside.

N7-Methyl-2'-O-(2-methoxyethyl) guanosine is a Nucleoside Derivative - 2'-Modified nucleoside, N-Methylated/ alkylated nucleoside.

N7-Methyl-3'-O-methyl guanosine is a Nucleoside Derivative - 3'-Modified nucleoside, N-Methylated/ alkylated nucleoside.

[DPro10] Dynorphin A (1-11), porcine hydrochloride, is an N-alkylated derivative and potent κ-opioid receptor agonist with a K i value of 0.13 nM, possessing analgesic properties [1] [2].

S2157, a potent N-alkylated tranylcypromine (TCP) derivative lysine-specific demethylase 1 (LSD1) inhibitor, enhances H3K9 methylation and concurrently reduces H3K27 acetylation at super-enhancer sites. This compound triggers apoptosis in TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells by inhibiting NOTCH3 and TAL1 gene expression. Moreover, S2157 is capable of crossing the blood-brain barrier, effectively eliminating central nervous system (CNS) leukemia in mice models implanted with T-ALL cells.

[DPro10] Dynorphin A (1-11), porcine, an N-Alkylated derivative, serves as a potent κ-opioid receptor agonist with a Ki value of 0.13 nM, exhibiting analgesic properties [1] [2].

N1-Propargylpseudouridine is a Nucleoside Derivative - C-nucleoside; N-Alkylated nucleoside.

2'-Deoxy-N4-ethyl-5-methylcytidine is a Nucleoside Derivative - N-Methylated alkylated nucleoside.

N3,5-Dimethyl-2'-O-(2-methoxyethyl) uridine is a Nucleoside Derivative - 2'-Modified nucleoside, N-Methylated/ alkylated nucleoside.

Nucleoside Derivatives - 2’-Modified nucleosides, Fluoro-modified nucleosides, N-Methylated /alkylated nucleosides

Nucleoside Derivatives - N-Methylated/ alkylated nucleosides; DNA adduct

N1-Methyl-2'-deoxy-2'-fluoroarabinoadenosine is a Nucleoside Derivative - 2'-Modified nucleoside, N-Methylated/alkylated nucleoside, Fluoro-modified nucleoside.

N3-Ethyl pseudouridine is a Nucleoside Derivative - C-nucleoside; N-Alkylated nucleoside.

Nucleoside Derivatives - Xylo=nucleosides, N-Methylated/ alkylated nucleosides

N1-Methyl-3'-O-(2-methoxyethyl) inosine is a Nucleoside Derivative - 3'-Modified nucleoside, N-Methylated/ alkylated nucleoside.

7-n-Propyl-7,8-dihydro-8-oxo-9-(beta-D-xylofuranosyl)guanine is a nucleoside derivative (xylo-nucleoside), N-methylated alkylated nucleoside, and an 8-modified purine nucleoside.

Nucleoside Derivatives - 2--Modified purine nucleosides; N-Alkylated nucleosides; Naturally modified ribo-nucleosides

2',3',5'-Tri-O-acetyl-5,N3-dimethyl uridine is a Nucleoside Derivative - N-Alkylated nucleoside.

Nucleoside Derivatives - 2-Modified purine nucleosides; 2’-Modified nucleosides; N-Alkylated nucleosides

TLR7 agonist 10 is a Nucleoside Derivative - Xylo-nucleoside, N-Methylated alkylated nucleoside; 8-Modified purine nucleoside.