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Phosphoramide mustard
🥰Excellent
Catalog No. T38410Cas No. 10159-53-2
Phosphoramide mustard is a toxic metabolite of cyclophosphamide with anticancer activity and ovarian toxicity that induces DNA damage.
Phosphoramide mustard
🥰Excellent
Catalog No. T38410Cas No. 10159-53-2
Phosphoramide mustard is a toxic metabolite of cyclophosphamide with anticancer activity and ovarian toxicity that induces DNA damage.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $293 | In Stock |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Phosphoramide mustard is a toxic metabolite of cyclophosphamide with anticancer activity and ovarian toxicity that induces DNA damage. |
| In vitro | In SIGCs cell lines, Phosphoramide mustard (0.5 μM, 1 μM, 3 μM, 6 μM; 48 hours) reduced cell viability[1]. |
| In vivo | In the rat model of subcutaneously implanted Walker 256 carcinosarcoma tumors, Phosphoramide mustard (12 mg/kg; intraperitoneal injection, once daily, for 5 consecutive days) inhibited subcutaneous tumor growth by 50%[2]. |
| Molecular Weight | 221.02 |
| Formula | C4H11Cl2N2O2P |
| Cas No. | 10159-53-2 |
| Smiles | O=P(O)(N)N(CCCl)CCCl |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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