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Primaquine
🥰Excellent
Catalog No. T60411Cas No. 90-34-6
Primaquine is an antimalarial compound and a gametocytocide, clearing liver schizonts and dormant forms of Plasmodium vivax.
Primaquine
🥰Excellent
Purity: 98.62%
Catalog No. T60411Cas No. 90-34-6
Primaquine is an antimalarial compound and a gametocytocide, clearing liver schizonts and dormant forms of Plasmodium vivax.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $31 | In Stock | |
| 50 mg | $42 | In Stock | |
| 100 mg | $50 | In Stock |
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Purity:98.62%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Primaquine is an antimalarial compound and a gametocytocide, clearing liver schizonts and dormant forms of Plasmodium vivax. |
| Targets&IC50 | EphB3:0.079 µM |
| In vitro | Methods: MDA-MB-231, HCC1937, MCF-7 and MDA-MB-453 cells were treated with Primaquine (5 μM, 10 μM, 20 μM, 40 μM, 80 μM, 100 μM, 120 μM and 150 μM for 24 hours) following the CellTiter 96® Aqueous One Solution Cell Kit protocol and the absorbance was read at 490 nm using SpectraMax. Results: Primaquine inhibited breast cancer cells with an IC50 value of 81.2 μM and had no inhibitory effect on the proliferation of MCF-7 (ER+) and MDA-MB-453 (HER2+) cells. [1] |
| In vivo | Methods: Twelve 4-week-old nude mice were injected with MDA-MB-231 cells and treated with Primaquine (2 mg/kg). Tumor volume was measured every 10 days after 90 days using the formula. Results: Primaquine inhibited tumor growth in a xenograft mouse model. [1] |
| Molecular Weight | 259.35 |
| Formula | C15H21N3O |
| Cas No. | 90-34-6 |
| Smiles | N=1C=CC=C2C=C(OC)C=C(NC(C)CCCN)C12 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 200 mg/mL (771.16 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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