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Propiolactone
😃Good
Catalog No. T81388Cas No. 57-57-8
Alias β-propiolactone, Betaprone, 2-Oxetanone
Propiolactone (β-propiolactone; 2-Oxetanone), a chemosterilant, effectively inactivates viruses, rendering them non-infectious. It has been utilized at a 1:1000 (v:v) ratio alongside SARS-CoV to create the BPL-inactivated influenza virus vaccine (Flu-BPL) [1] [2], additionally serving as a bacteriostatic agent.
Propiolactone
😃Good
Catalog No. T81388Alias β-propiolactone, Betaprone, 2-OxetanoneCas No. 57-57-8
Propiolactone (β-propiolactone; 2-Oxetanone), a chemosterilant, effectively inactivates viruses, rendering them non-infectious. It has been utilized at a 1:1000 (v:v) ratio alongside SARS-CoV to create the BPL-inactivated influenza virus vaccine (Flu-BPL) [1] [2], additionally serving as a bacteriostatic agent.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | 8-10 weeks | |
| 50 mg | Inquiry | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Propiolactone (β-propiolactone; 2-Oxetanone), a chemosterilant, effectively inactivates viruses, rendering them non-infectious. It has been utilized at a 1:1000 (v:v) ratio alongside SARS-CoV to create the BPL-inactivated influenza virus vaccine (Flu-BPL) [1] [2], additionally serving as a bacteriostatic agent. |
| In vitro | Propiolactone (β-propiolactone) is utilized for vaccine purification. |
| In vivo | Mice were immunized with inactivated influenza A virus using Propiolactone (β-propiolactone) (~25 mg total protein per dose; intramuscular injection). Post-inactivation with Propiolactone, the SARS was non-lethal to young BALB/c mice. Although the virus replicated in the mice's respiratory tract, it was cleared by day 5. Treatment with Propiolactone yielded 1.5 μg of total hemagglutinin protein, resulting in negative infection outcomes in the mice [1]. |
| Alias | β-propiolactone, Betaprone, 2-Oxetanone |
| Molecular Weight | 72.06 |
| Formula | C3H4O2 |
| Cas No. | 57-57-8 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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