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RBN-3143
🥰Excellent
Catalog No. T67844Cas No. 2360853-16-1
RBN-3143 is a potent inhibitor of NAD+-competitive catalytic PARP14 (IC50= 4 nM), which inhibits ADP-ribosylation mediated by PARP14 and stabilizes PARP14 in cell lines, demonstrating research potential for lung inflammation.
RBN-3143
🥰Excellent
Purity: 98.64%
Catalog No. T67844Cas No. 2360853-16-1
RBN-3143 is a potent inhibitor of NAD+-competitive catalytic PARP14 (IC50= 4 nM), which inhibits ADP-ribosylation mediated by PARP14 and stabilizes PARP14 in cell lines, demonstrating research potential for lung inflammation.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $87 | In Stock | |
| 5 mg | $213 | In Stock | |
| 10 mg | $313 | In Stock | |
| 25 mg | $533 | In Stock | |
| 50 mg | $768 | In Stock | |
| 100 mg | $1,080 | In Stock | |
| 500 mg | $2,160 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $235 | In Stock |
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Purity:98.64%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | RBN-3143 is a potent inhibitor of NAD+-competitive catalytic PARP14 (IC50= 4 nM), which inhibits ADP-ribosylation mediated by PARP14 and stabilizes PARP14 in cell lines, demonstrating research potential for lung inflammation. |
| Targets&IC50 | PARP14:4 nM |
| In vivo | RBN-3143 (5 μg; Intranasal administration) can improve the steroid resistant asthma mouse model [1]. |
| Molecular Weight | 449.54 |
| Formula | C22H28FN3O4S |
| Cas No. | 2360853-16-1 |
| Smiles | CC(=O)N1CCC(COc2cc(F)c3c(c2)nc(CSC2CCOCC2)[nH]c3=O)CC1 |
| Relative Density. | 1.41 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 11.2 mg/mL (25.0 mM), Sonication and heating to 80℃ are recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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