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RCGD423
Catalog No. T5359Cas No. 108237-91-8
RCGD423, a small molecule gp130 modulator, prevents articular cartilage degeneration and promotes repair.
RCGD423
Catalog No. T5359Cas No. 108237-91-8
RCGD423, a small molecule gp130 modulator, prevents articular cartilage degeneration and promotes repair.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $31 | In Stock | |
| 5 mg | $72 | In Stock | |
| 10 mg | $112 | In Stock | |
| 25 mg | $163 | In Stock | |
| 50 mg | $239 | In Stock | |
| 100 mg | $372 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $76 | In Stock |
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CitedSelect Batch
Purity:99.14%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | RCGD423, a small molecule gp130 modulator, prevents articular cartilage degeneration and promotes repair. |
| In vitro | The ability of RCGD 423 to inhibit hypertrophy in human cells was confirmed by assessing RUNX2 and COL 10 levels in healthy and osteoarthritic articular chondrocytes following incubation with the compound. RCGD 423 elicited a unique signaling profile, driving strong increases in pSTAT3 and MYC levels without activating AKT or NF-κB, resulting in a signaling milieu downstream of gp130 similar to actively proliferating and anabolic fetal chondrocytes. |
| In vivo | Operated animals would receive an intra-articular injection of 4 μg RCGD 423 loaded onto microspheres at the time of surgery and another 3weeks later. In RCGD 423-treated animals, there was little to no cartilage degradation, structural damage or generation of osteophytes. Control animals showed increased levels of cartilage-degrading proteins and markers of hypertrophy, while these were mostly absent in RCGD 423-treated rats. |
| Molecular Weight | 331.23 |
| Formula | C15H11BrN2S |
| Cas No. | 108237-91-8 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: Insoluble DMSO: 150 mg/mL (452.86 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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