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RCGD423

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Purity:99.14%

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COA HNMR LCMS HPLC

RCGD423

Catalog No. T5359Cas No. 108237-91-8

RCGD423, a small molecule gp130 modulator, prevents articular cartilage degeneration and promotes repair.

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Pack Size	Price	Availability
1 mg	$31	In Stock
5 mg	$72	In Stock
10 mg	$112	In Stock
25 mg	$163	In Stock
50 mg	$239	In Stock
100 mg	$372	In Stock
1 mL x 10 mM (in DMSO)	$76	In Stock

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Product Introduction

Bioactivity

Description	RCGD423, a small molecule gp130 modulator, prevents articular cartilage degeneration and promotes repair.
In vitro	The ability of RCGD 423 to inhibit hypertrophy in human cells was confirmed by assessing RUNX2 and COL 10 levels in healthy and osteoarthritic articular chondrocytes following incubation with the compound. RCGD 423 elicited a unique signaling profile, driving strong increases in pSTAT3 and MYC levels without activating AKT or NF-κB, resulting in a signaling milieu downstream of gp130 similar to actively proliferating and anabolic fetal chondrocytes.
In vivo	Operated animals would receive an intra-articular injection of 4 μg RCGD 423 loaded onto microspheres at the time of surgery and another 3weeks later. In RCGD 423-treated animals, there was little to no cartilage degradation, structural damage or generation of osteophytes. Control animals showed increased levels of cartilage-degrading proteins and markers of hypertrophy, while these were mostly absent in RCGD 423-treated rats.

Chemical Properties

Molecular Weight	331.23
Formula	C15H11BrN2S
Cas No.	108237-91-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

DMSO: 150 mg/mL (452.86 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0191 mL	15.0953 mL	30.1905 mL	150.9525 mL
5 mM	0.6038 mL	3.0191 mL	6.0381 mL	30.1905 mL
10 mM	0.3019 mL	1.5095 mL	3.0191 mL	15.0953 mL
20 mM	0.1510 mL	0.7548 mL	1.5095 mL	7.5476 mL
50 mM	0.0604 mL	0.3019 mL	0.6038 mL	3.0191 mL
100 mM	0.0302 mL	0.1510 mL	0.3019 mL	1.5095 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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