Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CAIX Inhibitor S4 (S4) is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively. The Kis for CA II and CA I are 546 and 5600 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 34.00 | |
5 mg | In stock | $ 55.00 | |
10 mg | In stock | $ 97.00 | |
25 mg | In stock | $ 198.00 | |
50 mg | In stock | $ 372.00 | |
100 mg | In stock | $ 556.00 | |
500 mg | In stock | $ 1,220.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 61.00 |
Description | CAIX Inhibitor S4 (S4) is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively. The Kis for CA II and CA I are 546 and 5600 nM. |
Targets&IC50 | CA I:5600 nM (Ki), CA II:546 nM (Ki), CA XII:2 nM (Ki), CA IX:7 nM (Ki) |
In vitro | CAIX Inhibitor S4 (33 μM; 15-60 min) delays the cell spreading of MDA-MB-231 cells in anoxia but essentially not in normoxia. CAIX Inhibitor S4 (1, 10, 100 μM; 24 h) inhibits the proliferation of MDA-MB-231, HCT116 and HT29 cells in a dose-dependent manner with IC50s of 481 μM, >1000 μM, and 20 μM, respectively. CAIX Inhibitor S4 (3.3-33 μM; 24 h) inhibits the eGFP-MDA-MB-231 cell migration in anoxia in a concentration-dependent manner[1]. |
In vivo | CAIX Inhibitor S4 (10 mg/kg; i.p.) inhibits the number of lung metastasis in orthotopic MDA-MB-231 mouse model without affecting primary tumor growth[1]. |
Synonyms | S4 |
Molecular Weight | 335.38 |
Formula | C15H17N3O4S |
CAS No. | 1330061-67-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 245 mg/mL (730.51 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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CAIX Inhibitor S4 1330061-67-0 Metabolism Carbonic Anhydrase CAIX Inhibitor S 4 lung S4 CAIX Inhibitor S-4 metastasis S-4 XII orthotopic Carbonate dehydratase Inhibitor inhibit S 4 tumor inhibitor