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CAIX Inhibitor S4

🥰Excellent
Catalog No. T36758Cas No. 1330061-67-0
Alias S4

CAIX Inhibitor S4 (S4) is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively. The Kis for CA II and CA I are 546 and 5600 nM.

CAIX Inhibitor S4

CAIX Inhibitor S4

🥰Excellent
Purity: 98.35%
Catalog No. T36758Alias S4Cas No. 1330061-67-0
CAIX Inhibitor S4 (S4) is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively. The Kis for CA II and CA I are 546 and 5600 nM.
Pack SizePriceAvailabilityQuantity
2 mg$34In Stock
5 mg$55In Stock
10 mg$97In Stock
25 mg$198In Stock
50 mg$372In Stock
100 mg$556In Stock
500 mg$1,220In Stock
1 mL x 10 mM (in DMSO)$61In Stock
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Purity:98.35%
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Product Introduction

Bioactivity
Description
CAIX Inhibitor S4 (S4) is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively. The Kis for CA II and CA I are 546 and 5600 nM.
Targets&IC50
CA IX:7 nM (Ki), CA I:5600 nM (Ki), CA II:546 nM (Ki), CA XII:2 nM (Ki)
In vitro
CAIX Inhibitor S4 (33 μM; 15-60 min) delays the cell spreading of MDA-MB-231 cells in anoxia but essentially not in normoxia. CAIX Inhibitor S4 (1, 10, 100 μM; 24 h) inhibits the proliferation of MDA-MB-231, HCT116 and HT29 cells in a dose-dependent manner with IC50s of 481 μM, >1000 μM, and 20 μM, respectively. CAIX Inhibitor S4 (3.3-33 μM; 24 h) inhibits the eGFP-MDA-MB-231 cell migration in anoxia in a concentration-dependent manner[1].
In vivo
CAIX Inhibitor S4 (10 mg/kg; i.p.) reduces lung metastasis in the orthotopic MDA-MB-231 mouse model without impacting primary tumor growth[1].
AliasS4
Chemical Properties
Molecular Weight335.38
FormulaC15H17N3O4S
Cas No.1330061-67-0
SmilesCc1cc(C)cc(NC(=O)Nc2ccc(OS(N)(=O)=O)cc2)c1
Relative Density.1.429 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 245 mg/mL (730.51 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9817 mL14.9085 mL29.8169 mL149.0846 mL
5 mM0.5963 mL2.9817 mL5.9634 mL29.8169 mL
10 mM0.2982 mL1.4908 mL2.9817 mL14.9085 mL
20 mM0.1491 mL0.7454 mL1.4908 mL7.4542 mL
50 mM0.0596 mL0.2982 mL0.5963 mL2.9817 mL
100 mM0.0298 mL0.1491 mL0.2982 mL1.4908 mL

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