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Tioxolone

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Purity:95.9%

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COA HNMR HPLC

Tioxolone

Catalog No. T0515Cas No. 4991-65-5

Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor.

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Pack Size	Price	Availability
500 mg	$39	In Stock
1 g	$57	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock

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Product Introduction

Bioactivity

Description	Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor.
In vitro	Tioxolone, along with its Benzoxathiol derivatives, exhibits antibacterial and antifungal properties, as well as inhibitory effects on cell proliferation. These compounds have been utilized in topical treatments for common psoriasis and acne.
In vivo	Tioxolone exhibits sebum-regulating and antibacterial properties, thus it is incorporated in various cosmetics such as shampoos and skin cleansers.

Chemical Properties

Molecular Weight	168.17
Formula	C7H4O3S
Cas No.	4991-65-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 32 mg/mL (190.3 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 45 mg/mL (267.59 mM)

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	5.9464 mL	29.7318 mL	59.4636 mL	297.3182 mL
5 mM	1.1893 mL	5.9464 mL	11.8927 mL	59.4636 mL
10 mM	0.5946 mL	2.9732 mL	5.9464 mL	29.7318 mL
20 mM	0.2973 mL	1.4866 mL	2.9732 mL	14.8659 mL
50 mM	0.1189 mL	0.5946 mL	1.1893 mL	5.9464 mL
100 mM	0.0595 mL	0.2973 mL	0.5946 mL	2.9732 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc