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SC-560

🥰Excellent
Catalog No. T4101Cas No. 188817-13-2
Alias SC560

SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors.

SC-560

SC-560

🥰Excellent
Purity: 99.97%
Catalog No. T4101Alias SC560Cas No. 188817-13-2
SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors.
Pack SizePriceAvailabilityQuantity
2 mg$33 In Stock
5 mg$52 In Stock
10 mg$93 In Stock
25 mg$198 In Stock
50 mg$252 In Stock
100 mg$323 In Stock
1 mL x 10 mM (in DMSO)$58 In Stock
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Purity:99.97%
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Product Introduction

Bioactivity
Description
SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors.
Targets&IC50
COX-1:9 nM.
In vitro
Preincubation of cyclooxygenase-1 (COX-1) with SC-560 selectively inhibits the conversion of arachidonic acid to prostaglandin E2 (PGE2) in a concentration-dependent manner, demonstrating higher specificity for COX-1 over COX-2, as indicated by SC-560's inhibitory concentration 50 (IC50) for COX-2 being 6.3 μM, nearly 1,000-fold greater than for COX-1. Furthermore, SC-560 has been shown to suppress hepatocellular carcinoma (HCC) cell growth, colony formation in soft agar, and induce apoptosis in a dose- and time-dependent manner. Additionally, it downregulates anti-apoptotic proteins, including survivin and X-linked inhibitor of apoptosis protein (XIAP), while simultaneously activating caspases 3 and 7, illustrating its therapeutic potential in HCC treatment through multifaceted mechanisms of action.
In vivo
Oral dosing with either 10 or 30 mg/kg SC-560 1 hour before assay completely inhibits ionophore-stimulated TxB2 production, indicating that SC-560 is orally bioavailable and inhibits COX-1 in vivo. SC-560 extensively distributes into rat tissues, with a CL approaching hepatic plasma flow. However, after oral administration, it exhibits low (<15%), formulation-dependent bioavailability and demonstrates kidney toxicity.
Kinase Assay
Test compound is incubated with human whole blood stimulated with bacterial LPS for 4 h, followed by capture of MPO on immobilized anti-MPO antibody coated plates. The captured MPO is washed and residual MPO activity is determined using Amplex Red and H2O2.
Cell Research
SC-560 is dissolved in DMSO[2].HuH-6 and HA22T/VGH cells (5000/well) are treated with various concentrations of SC-560 (5, 10, 25, 50, 100, 200 μM) and cultured for 72 h. At the end of treatment, cell viability is assessed by MTS assay.
Animal Research
Rat: The pharmacokinetics of SC-560 is studied in Sprague-Dawley rats after a single intravenous (i.v.) and oral dose (10 mg/kg) in polyethylene glycol (PEG) 600 and a single oral dose (10 mg/kg) in 1% methylcellulose (MC). Serial blood samples are collected via a catheter inserted in the right jugular vein and serum samples are analysed for SC-560 using reverse phase HPLC. After oral administration of SC-560 in PEG, urine is also collected for 24 h and analyzed for urinary sodium, chloride, and potassium as well as NAG.
AliasSC560
Chemical Properties
Molecular Weight352.74
FormulaC17H12ClF3N2O
Cas No.188817-13-2
SmilesCOc1ccc(cc1)-n1nc(cc1-c1ccc(Cl)cc1)C(F)(F)F
Relative Density.1.33g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 35.3 mg/mL (100.07 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8349 mL14.1747 mL28.3495 mL141.7475 mL
5 mM0.5670 mL2.8349 mL5.6699 mL28.3495 mL
10 mM0.2835 mL1.4175 mL2.8349 mL14.1747 mL
20 mM0.1417 mL0.7087 mL1.4175 mL7.0874 mL
50 mM0.0567 mL0.2835 mL0.5670 mL2.8349 mL
100 mM0.0283 mL0.1417 mL0.2835 mL1.4175 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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