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SIJ1777
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Catalog No. T200137Cas No. 839707-55-0
SIJ1777, a derivative of GNF-7, exhibits potent anticancer effects against melanoma cells harboring BRAFI/II/III mutations. The compound significantly inhibits the activation of MEK, ERK, and AKT. Furthermore, SIJ1777 notably induces apoptosis (cell death) and effectively prevents migration, invasion, and anchorage-independent growth of melanoma cells with BRAFI/II/III mutations.
SIJ1777
😃Good
Catalog No. T200137Cas No. 839707-55-0
SIJ1777, a derivative of GNF-7, exhibits potent anticancer effects against melanoma cells harboring BRAFI/II/III mutations. The compound significantly inhibits the activation of MEK, ERK, and AKT. Furthermore, SIJ1777 notably induces apoptosis (cell death) and effectively prevents migration, invasion, and anchorage-independent growth of melanoma cells with BRAFI/II/III mutations.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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Product Introduction
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Chemical Properties
| Description | SIJ1777, a derivative of GNF-7, exhibits potent anticancer effects against melanoma cells harboring BRAFI/II/III mutations. The compound significantly inhibits the activation of MEK, ERK, and AKT. Furthermore, SIJ1777 notably induces apoptosis (cell death) and effectively prevents migration, invasion, and anchorage-independent growth of melanoma cells with BRAFI/II/III mutations. |
| In vitro | SIJ1777 exhibits enhanced antiproliferative activity against melanoma cells (SK-MEL-2, SK-MEL-28, A375, WM3670, WM3629) compared to GNF-7, with a 2 to 14-fold increase. This enhancement is observed irrespective of the BRAF mutation status in the melanoma cells, where SIJ1777 completely inhibits the phosphorylation levels of MEK, -ERK, and -AKT at a concentration of 1 μM. Additionally, SIJ1777 increases the levels of cleaved PARP in a concentration-dependent manner in melanoma cells (SK-MEL-2, SK-MEL-28, C8161, WM3629). |
| Molecular Weight | 536.51 |
| Formula | C26H23F3N8O2 |
| Cas No. | 839707-55-0 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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