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Siltuximab
Siltuximab
Siltuximab（CNTO-328） is a monoclonal antibody with anti-tumor activity targeting IL-6 for the study of giant lymph node hyperplasia (MCD) and COVID-19.
Catalog No. T76978Cas No. 541502-14-1
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Concentration:9.32 mg/mL
Purity:95%
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Siltuximab
Catalog No. T76978Cas No. 541502-14-1
Siltuximab（CNTO-328） is a monoclonal antibody with anti-tumor activity targeting IL-6 for the study of giant lymph node hyperplasia (MCD) and COVID-19.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $178 | In Stock | |
| 5 mg | $439 | In Stock | |
| 10 mg | $648 | In Stock | |
| 25 mg | $987 | In Stock | |
| 50 mg | $1,390 | In Stock | |
| 100 mg | $1,870 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Siltuximab（CNTO-328） is a monoclonal antibody with anti-tumor activity targeting IL-6 for the study of giant lymph node hyperplasia (MCD) and COVID-19. |
| In vivo | In xenograft mouse models, Siltuximab, when administered through intraperitoneal injection at a dosage of 10 mg/kg three times per week, inhibits the growth of lung cancer cells[1]. Furthermore, in a xenograft model, the growth of MCF-7 tumors is inhibited by Siltuximab with intraperitoneal injections at a dose of 20 mg/kg twice per week for 6 weeks[3]. |
| Alias | CNTO-328 |
| Cas No. | 541502-14-1 |
Storage & Solubility Information
| Storage | store at low temperature | store at -80°C | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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