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Sivelestat sodium

Name: Sivelestat sodium
Brand: TargetMol
SKU: T21414
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21414Cas No. 150374-95-1

Alias ONO5046 sodium, ONO 5046 sodium, LY-544349 sodium, LY544349 sodium, EI546 sodium, EI 546 sodium

Sivelestat sodium (EI 546 sodium) is a highly efficient inhibitor of human neutrophil elastase, improving sepsis-induced myocardial dysfunction by activating the PI3K/AKT/mTOR signaling pathway. It can be used in acute lung injury/acute respiratory distress syndrome research.

Sivelestat sodium

😃Good

Catalog No. T21414Alias ONO5046 sodium, ONO 5046 sodium, LY-544349 sodium, LY544349 sodium, EI546 sodium, EI 546 sodiumCas No. 150374-95-1

Pack Size	Price	Availability	Quantity
2 mg	$30	In Stock
1 mL x 10 mM (in DMSO)	$77	5 days

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	Sivelestat sodium (EI 546 sodium) is a highly efficient inhibitor of human neutrophil elastase, improving sepsis-induced myocardial dysfunction by activating the PI3K/AKT/mTOR signaling pathway. It can be used in acute lung injury/acute respiratory distress syndrome research.
Targets&IC50	Neutrophil elastase (hamster):37 nM, Neutrophil elastase (rat):19 nM, Neutrophil elastase (rabbit):36 nM, Neutrophil elastase (human):200 nM (Ki), Neutrophil elastase (mouse):49 nM, Neutrophil elastase (human):44 nM
In vitro	Sivelestat sodium, a competitive inhibitor of human neutrophil elastase, has a Ki value of 200 nM, and does not inhibit trypsin, thrombin, fibrinolytic enzymes, plasma kallikrein-releasing enzyme, pancreatic kallikrein-releasing enzyme, chytolysin, or histone G, even at concentrations up to 100 μM. The IC50 values of Sivelestat sodium on neutrophil elastase in different species are 44 nM in humans, 36 nM in rabbits, 19 nM in rats, 37 nM in hamsters, and 49 nM in mice.[1]
In vivo	By intratracheal administration (0.021-2.1 mg/kg), Sivelestat sodium was able to effectively inhibit hamster lung hemorrhage induced by human neutrophil elastase (ID50 = 82 pg/kg), as well as the increase in guinea pig skin capillary permeability caused by i.v. administration (ID50 = 9.6 mg/kg). [1] Sivelestat sodium (10 mg/kg via tail vein infusion) ameliorated lung injury due to hemorrhagic shock in rats. [2] Sivelestat sodium was able to prevent ischemia-reperfusion injury in the bladder of rats by intraperitoneal injection (15 mg/kg and 60 mg/kg). [3]
Alias	ONO5046 sodium, ONO 5046 sodium, LY-544349 sodium, LY544349 sodium, EI546 sodium, EI 546 sodium

Chemical Properties

Molecular Weight	456.45
Formula	C₂₀H₂₁N₂NaO₇S
Cas No.	150374-95-1
Smiles	O=C(CNC(C1=C(NS(=O)(C2=CC=C(C=C2)OC(C(C)(C)C)=O)=O)C=CC=C1)=O)[O-].[Na+]
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 80.00 mg/mL (175.27 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1908 mL	10.9541 mL	21.9082 mL	109.5410 mL
5 mM	0.4382 mL	2.1908 mL	4.3816 mL	21.9082 mL
10 mM	0.2191 mL	1.0954 mL	2.1908 mL	10.9541 mL
20 mM	0.1095 mL	0.5477 mL	1.0954 mL	5.4771 mL
50 mM	0.0438 mL	0.2191 mL	0.4382 mL	2.1908 mL
100 mM	0.0219 mL	0.1095 mL	0.2191 mL	1.0954 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc