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SLF1081851

Catalog No. T61112   CAS 2763730-97-6

SLF1081851 is a Spns2 inhibitor. SLF1081851 inhibits S1P release with IC50 of 1.93 μM.

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SLF1081851 Chemical Structure
SLF1081851, CAS 2763730-97-6
Pack Size Availability Price/USD Quantity
1 mg In stock $ 51.00
5 mg In stock $ 122.00
10 mg In stock $ 197.00
25 mg In stock $ 422.00
50 mg In stock $ 628.00
100 mg In stock $ 893.00
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Purity: 98.57%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description SLF1081851 is a Spns2 inhibitor. SLF1081851 inhibits S1P release with IC50 of 1.93 μM.
In vitro SLF1081851 (compound 16d) (0-5 μM; 18-20 h) inhibits S1P release with an IC50 value of 1.93 μM in Hela cells[1]. SLF1081851 (0-30 μM; 20 min) inhibits mSphK1 (recombinant mouse SphK) (10 μM) and mSphK2 (5 μM) in a dose-dependent manner and suggests at least 15-fold selectivity (SphK1 IC50≥30 μM; SphK2 IC50≈30 μM)[1].
In vivo SLF1081851 (20 mg/kg; i.p., 4 h postdose) significantly inhibits circulating lymphocytes and plasma S1P. SLF1081851 recapitulates the genetic phenotype of Spns2 null mice[1].
Molecular Weight 343.51
Formula C21H33N3O
CAS No. 2763730-97-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 9.0 mg/mL (26.2 mM), sonification is recommended.

TargetMolReferences and Literature

1. Russell Fritzemeier, et al. Discovery of In Vivo Active Sphingosine-1-phosphate Transporter (Spns2) Inhibitors. J Med Chem. 2022 Jun 9;65(11):7656-7681.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max Inhibitor Library Bioactive Compound Library

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Keywords

SLF1081851 2763730-97-6 GPCR/G Protein LPL Receptor inhibitor inhibit

 

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