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Sonrotoclax

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Catalog No. T74637Cas No. 2383086-06-2
Alias BGB 11417

Sonrotoclax is a potent, orally active inhibitor of Bcl2, demonstrating effective cell-killing activity against a range of lymphoma and leukemia cell lines [1].

Sonrotoclax

Sonrotoclax

😃Good
Purity: 98.82%
Catalog No. T74637Alias BGB 11417Cas No. 2383086-06-2
Sonrotoclax is a potent, orally active inhibitor of Bcl2, demonstrating effective cell-killing activity against a range of lymphoma and leukemia cell lines [1].
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1 mg$372 7-10 days
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Purity:98.82%
ee:100%
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Product Introduction

Bioactivity
Description
Sonrotoclax is a potent, orally active inhibitor of Bcl2, demonstrating effective cell-killing activity against a range of lymphoma and leukemia cell lines [1].
In vivo
In Female NCG mice with acute lymphoblastic leukemia ( ALL ) xenografts, Sonrotoclax ( 5,15,50 mg / kg ; oral administration ; daily, for 42 days ) can inhibit tumor growth in a dose-dependent manner[1].
AliasBGB 11417
Chemical Properties
Molecular Weight890.10
FormulaC49H59N7O7S
Cas No.2383086-06-2
SmilesCC(C1=C(C=CC=C1)[C@H]2N(CCC2)C3CC4(CCN(C5=CC(OC6=CN=C(NC=C7)C7=C6)=C(C=C5)C(NS(=O)(C8=CC([N+]([O-])=O)=C(C=C8)NC[C@@H]9CC[C@@](O)(CC9)C)=O)=O)CC4)C3)C
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (89.88 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.1235 mL5.6173 mL11.2347 mL56.1735 mL
5 mM0.2247 mL1.1235 mL2.2469 mL11.2347 mL
10 mM0.1123 mL0.5617 mL1.1235 mL5.6173 mL
20 mM0.0562 mL0.2809 mL0.5617 mL2.8087 mL
50 mM0.0225 mL0.1123 mL0.2247 mL1.1235 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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