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SynuClean-D

SynuClean-D
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Purity:99.25%
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SynuClean-D

Catalog No. T13048Cas No. 685121-45-3
SynuClean-D (SC-D) is an α-synuclein aggregation inhibitor preventing fibril propagation, disrupting mature amyloid fibrils, and abolishing the degeneration of dopaminergic neurons in an animal model of Parkinson’s disease.
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Pack SizePriceAvailabilityQuantity
1 mg$177In Stock
5 mg$374In Stock
10 mg$597In Stock
25 mg$964In Stock
50 mg$1,290In Stock
100 mg$1,760In Stock
1 mL x 10 mM (in DMSO)$411In Stock
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Product Introduction

Bioactivity
Description
SynuClean-D (SC-D) is an α-synuclein aggregation inhibitor preventing fibril propagation, disrupting mature amyloid fibrils, and abolishing the degeneration of dopaminergic neurons in an animal model of Parkinson’s disease.
In vitro
SynuClean-D prevents fibril propagation in protein-misfolding cyclic amplification assays and decreases the number of α-synuclein inclusions in human neuroglioma cells. SynuClean-D significantly reduces the aggregation of wild-type α-synuclein and the familiar A30P and H50Q variants in a substoichiometric molar ratio. SynuClean-D can bind to cavities in mature α-synuclein fibrils[1].
In vivo
SynuClean-D-treated worms show decreased α-synuclein aggregation in muscle and a concomitant motility recovery. SynuClean-D is able to rescue dopaminergic neurons from α-synuclein-induced degeneration[1]. In two parkinson’s disease (PD) Caenorhabditis elegans models, SynuClean-D expresses α-synuclein either in muscle or in dopaminergic neurons and significantly reduces the toxicity exerted by α-synuclein[1].
AliasSC-D
Chemical Properties
Molecular Weight354.2
FormulaC13H5F3N4O5
Cas No.685121-45-3
Storage & Solubility Information
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 45 mg/mL (127.05 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8233 mL14.1163 mL28.2326 mL141.1632 mL
5 mM0.5647 mL2.8233 mL5.6465 mL28.2326 mL
10 mM0.2823 mL1.4116 mL2.8233 mL14.1163 mL
20 mM0.1412 mL0.7058 mL1.4116 mL7.0582 mL
50 mM0.0565 mL0.2823 mL0.5647 mL2.8233 mL
100 mM0.0282 mL0.1412 mL0.2823 mL1.4116 mL

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