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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $64 | In Stock | |
10 mg | $122 | In Stock | |
25 mg | $247 | In Stock | |
50 mg | $368 | In Stock | |
100 mg | $543 | In Stock | |
1 mL x 10 mM (in DMSO) | $70 | In Stock |
Description | TC-S 7009 is a potent and selective HIF-2α inhibitor (Kd: 81 nM). The affinity of TC-S 7009 to HIF-2α was higher than that of HIF-1α (Kd >> 5μM). TC-S 7009 disrupts HIF-2α heterodimerization, reduces HIF-2α target gene expression, and reduces dna binding activity. |
In vitro | TC-S 7009 (50 μM) treatment almost fully inhibits hypoxia-induced NFATc2 nuclear translocation. TC-S 7009 (0-100 µM; 72 hours; HPF cells) treatment displays greater inhibition of cell proliferation in hypoxic conditions than that in normoxic conditions [2]. |
Molecular Weight | 308.65 |
Formula | C12H6ClFN4O3 |
Cas No. | 1422955-31-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 45.0 mg/mL (145.8 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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