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Telomerase-IN-4
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Catalog No. T72789Cas No. 2892295-10-0
Telomerase-IN-4 is a potent telomerase inhibitor with antiproliferative properties and apoptosis-inducing effects [1].
Telomerase-IN-4
😃Good
Catalog No. T72789Cas No. 2892295-10-0
Telomerase-IN-4 is a potent telomerase inhibitor with antiproliferative properties and apoptosis-inducing effects [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Telomerase-IN-4 is a potent telomerase inhibitor with antiproliferative properties and apoptosis-inducing effects [1]. |
| In vitro | Telomerase-IN-4 (compound 8e; 0.1-100 μg/mL; 72 h) demonstrates antitumor activity against MCF-7 and A549 cancer cell lines, with IC50 values of 9.47 μg/mL and 17.09 μg/mL, respectively [1]. At 9.467 μg/mL over 48 hours, it induces S phase cell cycle arrest and apoptosis in MCF-7 cells [1]. |
| In vivo | Telomerase-IN-4, administered intraperitoneally at a dose of 5 mg/kg three times weekly over two weeks, exhibited anticancer activity by inhibiting tumor growth in albino female Swiss mice [1]. |
| Molecular Weight | 406.52 |
| Formula | C21H18N4OS2 |
| Cas No. | 2892295-10-0 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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