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Teneliximab
🥰Excellent
Catalog No. T76830Cas No. 299423-37-3
Alias Chi220, BMS 224819, Anti-Human CD40 Recombinant Antibody
Teneliximab (BMS 224819) is a chimeric monoclonal antibody and a tumor necrosis factor receptor superfamily member 5 (CD40) inhibitor that blocks CD40-CD40L interactions.Teneliximab exerts its partial agonist activity through CD40 and peripheral B-cell depletion, and may be used to study organ transplant rejection and rheumatoid arthritis.
Teneliximab
Teneliximab
🥰Excellent
Purity: 99.19% (SEC-HPLC)
Catalog No. T76830Alias Chi220, BMS 224819, Anti-Human CD40 Recombinant AntibodyCas No. 299423-37-3
Teneliximab (BMS 224819) is a chimeric monoclonal antibody and a tumor necrosis factor receptor superfamily member 5 (CD40) inhibitor that blocks CD40-CD40L interactions.Teneliximab exerts its partial agonist activity through CD40 and peripheral B-cell depletion, and may be used to study organ transplant rejection and rheumatoid arthritis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $163 | In Stock | |
| 5 mg | $428 | In Stock | |
| 10 mg | $662 | In Stock | |
| 25 mg | $987 | In Stock | |
| 50 mg | $1,370 | In Stock | |
| 100 mg | $1,850 | In Stock | |
| 200 mg | $2,490 | In Stock |
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Concentration:4.08 mg/mL
Purity:99.19% (SEC-HPLC)
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Teneliximab (BMS 224819) is a chimeric monoclonal antibody and a tumor necrosis factor receptor superfamily member 5 (CD40) inhibitor that blocks CD40-CD40L interactions.Teneliximab exerts its partial agonist activity through CD40 and peripheral B-cell depletion, and may be used to study organ transplant rejection and rheumatoid arthritis. |
| In vitro | METHODS: Monocytes were freshly prepared from human blood samples. Cells were cultured with anti-IgM immunoglobulin (5 μg/ml) and Teneliximab (BMS 224819) (5 μg/ml). The effect on cell proliferation was further evaluated. RESULTS Teneliximab (BMS 224819) promoted the proliferation of stimulated B cells. [1] |
| In vivo | METHODS: Crab monkey groups were immunized with SRBC and received a single intravenous dose of Teneliximab (BMS 224819) at 10, 40, or 100 mg/kg to observe the ability of Teneliximab (BMS 224819) to inhibit primary Ab responses in vivo. RESULTS Significant inhibition of the primary humoral immune response to SRBC by Teneliximab (BMS 224819) was observed at all three dose levels. [1] |
| Alias | Chi220, BMS 224819, Anti-Human CD40 Recombinant Antibody |
| Molecular Weight | 146.06 kDa |
| Cas No. | 299423-37-3 |
Storage & Solubility Information
| Storage | store at low temperature | store at -80°C | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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