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Tetrahydrofolic acid

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Catalog No. T21367Cas No. 135-16-0
Alias th-folate, Tetrahydropteroylglutamic acid, folate-H4, 5,6,7,8-tetrahydrofolic acid

Tetrahydrofolic acid (5,6,7,8-tetrahydrofolic acid) is a vitamin B9 derivative that is a common one-carbon donor in organisms and is involved in growth and metabolism.

Tetrahydrofolic acid

Tetrahydrofolic acid

🥰Excellent
Catalog No. T21367Alias th-folate, Tetrahydropteroylglutamic acid, folate-H4, 5,6,7,8-tetrahydrofolic acidCas No. 135-16-0
Tetrahydrofolic acid (5,6,7,8-tetrahydrofolic acid) is a vitamin B9 derivative that is a common one-carbon donor in organisms and is involved in growth and metabolism.
Pack SizePriceAvailabilityQuantity
5 mg$30In Stock
10 mg$40In Stock
25 mg$69In Stock
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Product Introduction

Bioactivity
Description
Tetrahydrofolic acid (5,6,7,8-tetrahydrofolic acid) is a vitamin B9 derivative that is a common one-carbon donor in organisms and is involved in growth and metabolism.
In vitro
In Adh5-/- DT40 cells, Tetrahydrofolic acid (0-200 µM; 3 days) resulted in a rapid drop in cell viability[1].
In vivo
In Adh5-/- mice, Tetrahydrofolic acid (62.5 mg/kg; intraperitoneal injection; daily) resulted in disrupted hematopoiesis, increased phosphorylation of Ser139-H2AX, and decreased survival of hematopoietic stem and progenitor cells (HSPCs)[1].
Aliasth-folate, Tetrahydropteroylglutamic acid, folate-H4, 5,6,7,8-tetrahydrofolic acid
Chemical Properties
Molecular Weight445.43
FormulaC19H23N7O6
Cas No.135-16-0
SmilesNc1nc2NCC(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)Nc2c(=O)[nH]1
Relative Density.1.7g/cm3
Storage & Solubility Information
Storagestore under nitrogen,keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 1 mg/mL (2.25 mM), Sonication is recommended.
H2O: 1 mg/mL (2.25 mM), Sonication is recommended.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM2.2450 mL11.2251 mL22.4502 mL112.2511 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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