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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $198 | 35 days | |
5 mg | $791 | 35 days | |
10 mg | $1,410 | 35 days |
Description | TG2-179-1 is a BRCA1-associated protein 1 (BAP1) inhibitor that effectively hampers BAP1's deubiquitinase activity in cell-free assays at concentrations between 25 µM and 1.5 mM. This compound exhibits cytotoxicity towards a range of eight colon cancer cell lines, with half-maximal inhibitory concentrations (IC50s) spanning from 4.48 to 7.52 µM. Additionally, in an HCT116 colon cancer mouse xenograft model, TG2-179-1 administration at doses of 10 and 30 mg/kg significantly reduces tumor volume, demonstrating its potential in vivo efficacy against colon cancer. |
Molecular Weight | 484.96 |
Formula | C22H14ClFN4O2S2 |
Cas No. | 1135023-19-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | DMF: 2 mg/ml Ethanol: 2 mg/ml DMSO: 1 mg/ml |
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