Shopping Cart
- Remove All
- Your shopping cart is currently empty
TH1338 is an orally active derivative of camptothecin with potential anti-cancer activity. TH1338 exhibits significant blood-brain barrier penetration and cytotoxicity, useful for cancer research.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,290 | In Stock | |
50 mg | $1,680 | In Stock | |
100 mg | $2,550 | In Stock |
Description | TH1338 is an orally active derivative of camptothecin with potential anti-cancer activity. TH1338 exhibits significant blood-brain barrier penetration and cytotoxicity, useful for cancer research. |
In vitro | The IC50 values of TH1338 against H460, PC-3 HT29, SK-MEL-2 and A375 were 7 nM, 24 nM, 300 nM, 130 nM and 7 nM, respectively. [1] |
In vivo | TH1338 (50 mg/kg orally) showed significant brain permeability. TH1338 (40 mg/kg, orally) showed 84% tumor growth inhibition in H460 xenograft models. [1] |
Alias | TH-1318 |
Molecular Weight | 391.42 |
Formula | C22H21N3O4 |
Cas No. | 1258494-60-8 |
Smiles | NC1=C2C=3C(CN2C(=O)C4=C1[C@](CC)(O)C(=O)OC4)=C(CC)C=5C(N3)=CC=CC5 |
Relative Density. | 1.47 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 8 mg/mL (20.44 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.