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THIQ

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Purity:98.93%

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COA HPLC HNMR

THIQ

Catalog No. T8485Cas No. 312637-48-2

THIQ is a selective melanocortin-4 receptor (MC4R) agonist (hMC4R and rMC4R with IC50 of 1.2 nM and 0.6 nM , respectively).

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Pack Size	Price	Availability
1 mg	$48	In Stock
2 mg	$67	In Stock
5 mg	$98	In Stock
10 mg	$189	In Stock
25 mg	$393	In Stock
50 mg	$596	In Stock
100 mg	$893	In Stock
1 mL x 10 mM (in DMSO)	$136	In Stock

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Product Introduction

Bioactivity

Description	THIQ is a selective melanocortin-4 receptor (MC4R) agonist (hMC4R and rMC4R with IC50 of 1.2 nM and 0.6 nM , respectively).
Targets&IC50	MC4R (rat):0.6 nM, MC4R (human):1.2 nM
In vitro	THIQ,?a small molecule agonist of the MC4R, on the cell surface expression and signaling of ten intracellularly retained MC4R mutants using different cell lines.?THIQ increased the cell surface expression of three mutants (N62S, C84R, and C271Y) and two of them (N62S and C84R) had increased signaling in HEK293 cells.THIQ increased the signaling of two other mutants (P78L and P260Q) without increasing their cell surface expression in HEK293 cells.?In neuronal cells, THIQ exhibited a more potent effect, correcting the cell surface expression and signaling of seven mutants (N62S, I69R, P78L, C84R, W174C, P260Q, and C271Y).

Chemical Properties

Molecular Weight	589.17
Formula	C33H41ClN6O2
Cas No.	312637-48-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 245 mg/mL (415.84 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6973 mL	8.4865 mL	16.9730 mL	84.8651 mL
5 mM	0.3395 mL	1.6973 mL	3.3946 mL	16.9730 mL
10 mM	0.1697 mL	0.8487 mL	1.6973 mL	8.4865 mL
20 mM	0.0849 mL	0.4243 mL	0.8487 mL	4.2433 mL
50 mM	0.0339 mL	0.1697 mL	0.3395 mL	1.6973 mL
100 mM	0.0170 mL	0.0849 mL	0.1697 mL	0.8487 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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