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Tildrakizumab
Tildrakizumab
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Tildrakizumab
Catalog No. T76784Cas No. 1326244-10-3
Tildrakizumab (SCH 900222) is a potent humanized monoclonal antibody against IL-23 (p19 subunit). Tildrakizumab targets single-stranded IL-23 with a Kd value of 136 pM. Tildrakizumab can be used to study psoriasis and psoriasis.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $328 | In Stock | |
| 5 mg | $863 | In Stock | |
| 10 mg | $1,380 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Tildrakizumab (SCH 900222) is a potent humanized monoclonal antibody against IL-23 (p19 subunit). Tildrakizumab targets single-stranded IL-23 with a Kd value of 136 pM. Tildrakizumab can be used to study psoriasis and psoriasis. |
| In vitro | Tildrakizumab inhibits IL-23-induced STAT3 signaling in HeLa cells expressing human IL-23Rα and IL-12Rβ1 receptors, with an IC50 of 23 pM[2]. Tildrakizumab reduces the affinity of IL-23 for IL-23Rα through negative allosteric modulation[2]. |
| In vivo | Tildrakizumab (100 mg/kg, subcutaneous injection, every two weeks, up to 9 months) demonstrates good tolerability in cynomolgus monkeys (toxicity study)[3]. |
| Alias | MK 3222, SCH 900222 |
| Molecular Weight | 144.4 (kDa) |
| Cas No. | 1326244-10-3 |
| Storage | store at low temperature store at -80°C |
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