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Tilogotamab

🥰Excellent
Catalog No. T80984Cas No. 2109731-10-2
Alias Hx-DR5-01/05, HexaBody-DR5/DR5, GEN-1029, GEN1029

Tilogotamab (GEN-1029) is an agonistic hexameric complex targeting two independent epitopes on DR5, used for studying multiple myeloma (MM).

Tilogotamab

Tilogotamab

🥰Excellent
Purity: 95%
Catalog No. T80984Alias Hx-DR5-01/05, HexaBody-DR5/DR5, GEN-1029, GEN1029Cas No. 2109731-10-2
Tilogotamab (GEN-1029) is an agonistic hexameric complex targeting two independent epitopes on DR5, used for studying multiple myeloma (MM).
Pack SizePriceAvailabilityQuantity
1 mg$258 In Stock
5 mg$568 In Stock
10 mg$910 In Stock
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Concentration:2.82 mg/mL
Purity:95%
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Product Introduction

Bioactivity
Description
Tilogotamab (GEN-1029) is an agonistic hexameric complex targeting two independent epitopes on DR5, used for studying multiple myeloma (MM).
In vitro
Tilogotamab (20 μg/mL,24h) induced strong cytotoxicity in primary multiple myeloma (MM) cells. [1]
In vivo
Tilogotamab at a concentration of 20 μg/mL for 24 hours exhibits potent cytotoxicity against primary MM cells [1]. Tilogotamab is a mixture of two non-competitive DR5-specific monoclonal immunoglobulin G1 (IgG1) antibodies, each featuring an E430G mutation in the Fc domain. This mutation enhances Fc-Fc interactions, leading to antibody hexamerization and subsequent FcγR-independent clustering of DR5 molecules [1].
AliasHx-DR5-01/05, HexaBody-DR5/DR5, GEN-1029, GEN1029
Chemical Properties
Cas No.2109731-10-2
Storage & Solubility Information
Storagestore at low temperature | store at -20°C | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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