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Tipifarnib (S enantiomer)

🥰Excellent
Catalog No. T17102Cas No. 192185-71-0
Alias Tipifarnib S enantiomer, IND-58359 S enantiomer, (S)-Tipifarnib, (S)-(-)-R-115777

Tipifarnib S enantiomer ((S)-(-)-R-115777) is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase inhibitor (IC50: 0.6 nM).

Tipifarnib (S enantiomer)

Tipifarnib (S enantiomer)

🥰Excellent
Purity: 99.05%
Catalog No. T17102Alias Tipifarnib S enantiomer, IND-58359 S enantiomer, (S)-Tipifarnib, (S)-(-)-R-115777Cas No. 192185-71-0
Tipifarnib S enantiomer ((S)-(-)-R-115777) is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase inhibitor (IC50: 0.6 nM).
Pack SizePriceAvailabilityQuantity
1 mg$47In Stock
5 mg$109In Stock
10 mg$175In Stock
25 mg$316In Stock
50 mg$455In Stock
100 mg$642In Stock
200 mg$865In Stock
1 mL x 10 mM (in DMSO)$117In Stock
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Purity:99.05%
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Product Introduction

Bioactivity
Description
Tipifarnib S enantiomer ((S)-(-)-R-115777) is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase inhibitor (IC50: 0.6 nM).
AliasTipifarnib S enantiomer, IND-58359 S enantiomer, (S)-Tipifarnib, (S)-(-)-R-115777
Chemical Properties
Molecular Weight489.4
FormulaC27H22Cl2N4O
Cas No.192185-71-0
SmilesCn1cncc1[C@](N)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1
Relative Density.1.33 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 25 mg/mL (51.08 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0433 mL10.2166 mL20.4332 mL102.1659 mL
5 mM0.4087 mL2.0433 mL4.0866 mL20.4332 mL
10 mM0.2043 mL1.0217 mL2.0433 mL10.2166 mL
20 mM0.1022 mL0.5108 mL1.0217 mL5.1083 mL
50 mM0.0409 mL0.2043 mL0.4087 mL2.0433 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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