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Torbafylline
🥰Excellent
Catalog No. T67965Cas No. 105102-21-4
Torbafylline, a xanthine derivative, is a phosphodiesterase (PDE) inhibitor that attenuates burn-induced protein hydrolysis in rat skeletal muscle through activation of the PDE4/cAMP/EPAC/PI3K/Akt pathway, and inhibits the enhanced ubiquitin-proteasome-dependent protein hydrolysis in skeletal muscle of cancer- and sepsis-prone rats.
Torbafylline
🥰Excellent
Purity: 99%
Catalog No. T67965Cas No. 105102-21-4
Torbafylline, a xanthine derivative, is a phosphodiesterase (PDE) inhibitor that attenuates burn-induced protein hydrolysis in rat skeletal muscle through activation of the PDE4/cAMP/EPAC/PI3K/Akt pathway, and inhibits the enhanced ubiquitin-proteasome-dependent protein hydrolysis in skeletal muscle of cancer- and sepsis-prone rats.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $130 | In Stock | |
| 5 mg | $320 | In Stock | |
| 10 mg | $480 | In Stock | |
| 25 mg | $786 | In Stock | |
| 50 mg | $1,080 | In Stock | |
| 100 mg | $1,480 | In Stock | |
| 500 mg | $2,960 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $331 | In Stock |
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Purity:99%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Torbafylline, a xanthine derivative, is a phosphodiesterase (PDE) inhibitor that attenuates burn-induced protein hydrolysis in rat skeletal muscle through activation of the PDE4/cAMP/EPAC/PI3K/Akt pathway, and inhibits the enhanced ubiquitin-proteasome-dependent protein hydrolysis in skeletal muscle of cancer- and sepsis-prone rats. |
| In vivo | Torbafylline (25 mg/kg per day; oral; three weeks) decreased fatigue to 68%. The blood flow in ligated muscles increased to a much smaller extent than in control muscles, and this smaller increase was attenuated by Torbafylline. A chronic decrease in the blood supply resulted in a significant shortening of the running time.[1] Torbafylline (25 mg/kg p.o.; 2 times a day; 2 weeks) decrease in running time was reversed by chronic treatment of Torbafylline. This improved performance may be explained by a decreased accumulation of lactate in muscles with a limited blood supply due to the effect of Torbafylline to increase the release of lactate from ischaemic muscles.[1] |
| Molecular Weight | 338.4 |
| Formula | C16H26N4O4 |
| Cas No. | 105102-21-4 |
| Smiles | C(OCC)N1C2=C(N(C)C(=O)N(CCCCC(C)(C)O)C2=O)N=C1 |
| Relative Density. | 1.25 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 25 mg/mL (73.88 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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